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成人系统性红斑狼疮患者认知功能的个体内变化:一项超过7年的马尔可夫分析

ACR Open Rheumatology Pub Date : 2023-03-01 DOI:10.1002/acr2.11529
Stefan Perera, Richard Cook, Ker-Ai Lee, Patti Katz, Zahi Touma
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引用次数: 1

摘要

目的:认知障碍在系统性红斑狼疮(SLE)中普遍存在。在认知和系统性红斑狼疮的纵向认识上仍存在空白。随着时间的推移，我们研究了SLE患者认知的个体变化。方法:数据来自加州大学旧金山分校狼疮结局研究，其中包括1281名成年SLE患者。霍普金斯语言学习测试(HVLT-R)和控制口语单词联想测试(COWAT)每年进行一次，持续7年。一种双态马尔可夫分析被用于模拟认知变化概率的转移强度。逻辑回归检验了临床变量与认知变化之间的关系。结果:在马尔可夫分析中观察到认知状态之间的最小转换。使用COWAT，自我报告的抑郁水平越高，认知改善的可能性越低(相对危险度[RR]: 0.98;95%可信区间[CI]: 0.96-0.99)，较高的自我报告疾病严重程度与认知能力下降相关(RR: 1.05;95% ci: 1.02-1.09)。使用HVLT-R，增加年龄(RR: 1.02;95% CI: 1.01-1.03)和高等教育水平(RR: 1.82;95% CI: 1.28-2.58)与认知改善和较高的自我报告疾病严重程度相关(RR: 1.02;95% CI: 1.01-1.03)和抑郁(RR: 1.05;95% CI: 1.03-1.07)与认知能力下降有关。结论:大多数SLE患者没有在高(Z评分≥-1.5)和低(Z评分)状态之间转换
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Intraindividual Change in Cognitive Function Among Adults With Systemic Lupus Erythematosus: A Markov Analysis Over 7 Years.

Intraindividual Change in Cognitive Function Among Adults With Systemic Lupus Erythematosus: A Markov Analysis Over 7 Years.

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Intraindividual Change in Cognitive Function Among Adults With Systemic Lupus Erythematosus: A Markov Analysis Over 7 Years.
Cognitive impairment is prevalent in systemic lupus erythematosus (SLE). There remain gaps in understanding cognition and SLE longitudinally. We studied intraindividual change in cognition in SLE over time.
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ACR Open Rheumatology
ACR Open Rheumatology
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