对合并高甘油三酯血症和低ldl -胆固醇患者的ldl -胆固醇计算公式的评价:是否有一个更好的公式?

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Vanda Barakett-Hamadé, Jean Pierre Ghayad, Ghassan Sleilaty
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引用次数: 0

摘要

在伴有高甘油三酯血症和低LDL-C的患者中,可靠地估计低密度脂蛋白胆固醇(LDL-C)是至关重要的。我们回顾性地比较了Friedewald (LDL-F)、Martin-Hopkins (LDL-MH)和Sampson (LDL-SA)方程与直接均匀LDL-C测定(dLDL-C)的性能,观察到轻度高甘油三酯血症(甘油三酯在1.69至3.9 mmol/L之间)和低LDL-C (< 2.58 mmol/L)。观察结果根据LDL-C进行分层。使用类内相关系数(ICC)(一致性截止值为0.9)和Bland-Altman图分析来评估方程与dLDL-C的一致性。独立于评估的LDL-C地层,这三个方程未能满足0.9 ICC的临界值,尽管它们与LDL-C的一致性随着LDL-C的增加而提高。Bland-Altman图分析显示LDL-F与LDL-C呈向下的不一致,LDL-MH和LDL-SA与直接LDL-C呈向上的不一致。LDL-MH在Bland-Altman协议范围之外的观察结果最少。虽然对于低LDL-C并伴有高甘油三酯血症的患者,没有任何方程可以被认为足以令人满意地取代直接测定,但LDL-MH在估计这些患者的LDL-C方面似乎比其他方程表现更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of equations for calculating LDL-cholesterol in patients with concomitant hypertriglyceridemia and low LDL-cholesterol: is there a preferred equation?

It is critical to reliably estimate Low Density Lipoprotein Cholesterol (LDL-C) in patients with concomitant hypertriglyceridemia and low LDL-C. We retrospectively compared the performances of the Friedewald (LDL-F), Martin-Hopkins (LDL-MH) and Sampson (LDL-SA) equations against a direct homogeneous LDL-C assay (dLDL-C) on observations presenting mild hypertriglyceridemia (triglycerides between 1.69 and 3.9 mmol/L) and low LDL-C (< 2.58 mmol/L). Observations were stratified according to their LDL-C. Agreement of the equations with dLDL-C was assessed using Intraclass Correlation Coefficients (ICC) with an agreement cut-off of 0.9, and analysis of Bland-Altman plots. Independently of the LDL-C stratum evaluated, the three equations failed to meet the 0.9 ICC cut-off, although their agreement with dLDL-C improves as LDL-C increases. Analysis of Bland-Altman plots shows a downwards discordance of LDL-F with dLDL-C, and an upwards discordance of LDL-MH and LDL-SA with direct LDL-C. LDL-MH resulted in the least observations outside the Bland-Altman limits of agreement. While no equation can be deemed satisfactory enough to replace direct assays in patients with low LDL-C and concomitant hypertriglyceridemia, LDL-MH seems to perform better than the other equations in estimating LDL-C in these patients.

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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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