能量平衡与骨骼健康:营养供应的视角。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Current Osteoporosis Reports Pub Date : 2023-02-01 Epub Date: 2022-12-21 DOI:10.1007/s11914-022-00765-4
Beatriz Bermudez, Toru Ishii, Yuan-Haw Wu, R Dana Carpenter, Vanessa D Sherk
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引用次数: 0

摘要

审查目的:肥胖症发病率很高,与骨质脆弱和骨折有关。肥胖症患者骨骼营养供应的变化是骨骼健康的一个重要方面。本文旨在总结目前有关碳水化合物和膳食脂肪对骨骼影响的知识,特别是在其他组织的背景下:骨骼是吸收脂肪酸和葡萄糖的主要部位。碳水化合物和脂肪进入组织的途径会随着体重减轻和体重增加而发生变化。运动会剧烈影响骨骼对营养物质的吸收,并可能影响骨骼对营养物质的分配。骨细胞会分泌激素,向大脑和其他组织传递有关其能量状态的信息,这可能会改变全身营养物质的运输。目前亟需开展研究,探讨新陈代谢紊乱对骨骼中营养物质供应的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Energy Balance and Bone Health: a Nutrient Availability Perspective.

Purpose of review: Obesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone in obesity is an important facet of bone health. The goal of this article is to summarize current knowledge on the effects of carbohydrate and dietary fat availability on bone, particularly in the context of other tissues.

Recent findings: The skeleton is a primary site for fatty acid and glucose uptake. The trafficking of carbohydrates and fats into tissues changes with weight loss and periods of weight gain. Exercise acutely influences nutrient uptake into bone and may affect nutrient partitioning to bone. Bone cells secrete hormones that signal to the brain and other tissues information about its energetic state, which may alter whole-body nutrient trafficking. There is a critical need for studies to address the changes that metabolic perturbations have on nutrient availability in bone.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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