L. Artese , D.A. Di Stefano , G. Iezzi , M. Piccirilli , S. Pagnutti , G. di Gregorio , V. Perrotti
{"title":"马骨替代物治疗下颌萎缩:一项人体免疫组织化学研究","authors":"L. Artese , D.A. Di Stefano , G. Iezzi , M. Piccirilli , S. Pagnutti , G. di Gregorio , V. Perrotti","doi":"10.1016/j.ios.2012.03.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p><span>To perform an immunohistochemical evaluation of microvessel density (MVD), vascular endothelial growth factor (VEGF) and </span>nitric oxide synthase<span> (NOS) expression in mandibular ridge regeneration using an equine-derived bone substitute.</span></p></div><div><h3>Materials and methods</h3><p>Ridge augmentations were performed in six patients using equine bone. After a six-month healing period, four bone cores from no augmented (control) and four from augmented sites (test) were retrieved and processed for immunohistochemistry.</p></div><div><h3>Results</h3><p>Statistically, significant differences were found in the MVD expression between control and test sites (p<!--> <!--><<!--> <!-->0.05). The high and low intensities of VEGF, NOS1 and NOS3 were mainly expressed in test samples with statistical differences with control (p<!--> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Within the limits of the small sample size, the present study indicated that equine bone is able to support neovascularization when used as a grafting material.</p></div>","PeriodicalId":100732,"journal":{"name":"Italian Oral Surgery","volume":"11 5","pages":"Pages 81-89"},"PeriodicalIF":0.0000,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ios.2012.03.008","citationCount":"1","resultStr":"{\"title\":\"Treatment of mandibular atrophy by an equine bone substitute: an immunohistochemical study in man\",\"authors\":\"L. Artese , D.A. Di Stefano , G. Iezzi , M. Piccirilli , S. Pagnutti , G. di Gregorio , V. Perrotti\",\"doi\":\"10.1016/j.ios.2012.03.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p><span>To perform an immunohistochemical evaluation of microvessel density (MVD), vascular endothelial growth factor (VEGF) and </span>nitric oxide synthase<span> (NOS) expression in mandibular ridge regeneration using an equine-derived bone substitute.</span></p></div><div><h3>Materials and methods</h3><p>Ridge augmentations were performed in six patients using equine bone. After a six-month healing period, four bone cores from no augmented (control) and four from augmented sites (test) were retrieved and processed for immunohistochemistry.</p></div><div><h3>Results</h3><p>Statistically, significant differences were found in the MVD expression between control and test sites (p<!--> <!--><<!--> <!-->0.05). The high and low intensities of VEGF, NOS1 and NOS3 were mainly expressed in test samples with statistical differences with control (p<!--> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Within the limits of the small sample size, the present study indicated that equine bone is able to support neovascularization when used as a grafting material.</p></div>\",\"PeriodicalId\":100732,\"journal\":{\"name\":\"Italian Oral Surgery\",\"volume\":\"11 5\",\"pages\":\"Pages 81-89\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ios.2012.03.008\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Italian Oral Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1827245212000992\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Oral Surgery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1827245212000992","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Treatment of mandibular atrophy by an equine bone substitute: an immunohistochemical study in man
Objective
To perform an immunohistochemical evaluation of microvessel density (MVD), vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS) expression in mandibular ridge regeneration using an equine-derived bone substitute.
Materials and methods
Ridge augmentations were performed in six patients using equine bone. After a six-month healing period, four bone cores from no augmented (control) and four from augmented sites (test) were retrieved and processed for immunohistochemistry.
Results
Statistically, significant differences were found in the MVD expression between control and test sites (p < 0.05). The high and low intensities of VEGF, NOS1 and NOS3 were mainly expressed in test samples with statistical differences with control (p < 0.05).
Conclusions
Within the limits of the small sample size, the present study indicated that equine bone is able to support neovascularization when used as a grafting material.
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