致病性钩端螺旋体鞘磷脂酶2 (Sph2)体液应答表位靶点的计算机识别

Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI:10.35259/isi.2022_52218

Laura Ataídes, Fernanda Maia, F. Conte, Rodrigo Silva

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摘要

1，肽2的类似模式，其中5%的非反应性样品(4)呈现针对该肽的抗体。结论:利用免疫信息学方法可鉴定出该蛋白的2个表位。ELISA试验可以评估肽1和肽2对患者血清中存在的抗体的免疫原性。我们相信这项研究可以促进钩端螺旋体病疫苗研究的进展。

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In silico identification of epitopes target of humoral response against Sphingomyelinase 2 (Sph2) of pathogenic Leptospira

1, a similar pattern of peptide 2, where 5% of the non-reactive samples (4) presented antibodies against this peptide. Conclusion: Through immunoinformatics it was possible to identify 2 epitopes in this protein. The ELISA tests allowed the evaluation of the immunogenicity of peptides 1 and 2 against antibodies present in the serum of patients. We believe that this study can contribute to advances in vaccine research against leptospirosis.

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Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes

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