基质结合纳米囊泡:它们是什么?它们有什么作用?

IF 2.9 4区 生物学 Q1 ANATOMY & MORPHOLOGY
Logan M Piening, Rebecca A Wachs
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引用次数: 2

摘要

在过去的50年里,已经发现了几种不同类型的细胞外囊泡,包括外泌体、微囊泡和基质囊泡。这些囊泡是由细胞为特定目的分泌的,含有微rna、细胞因子和脂质等货物。最近发现了一种新的细胞外囊泡——基质结合纳米囊泡(MBV)。MBV与微泡相似,但它附着在细胞外基质上,而不是分泌。本文将mbv与其他类型的细胞外囊泡进行比较,试图更好地了解它们的起源和功能。此外,本综述将解释各种细胞外囊泡分离方法及其如何用于MBV,并总结MBV货物的特性,如microRNA,蛋白质和脂质。最后,我们将总结mbv对细胞的作用。mbv是一类新型的细胞外囊泡,作为靶向基因和药物治疗的传递平台具有很大的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Matrix-Bound Nanovesicles: What Are They and What Do They Do?

Over the past 50 years, several different types of extracellular vesicles have been discovered including exosomes, microvesicles, and matrix vesicles. These vesicles are secreted by cells for specific purposes and contain cargo such as microRNA, cytokines, and lipids. A novel extracellular vesicle, the matrix-bound nanovesicle (MBV), has been recently discovered. The MBV is similar to the microvesicle, however, it is attached to the extracellular matrix, instead of being secreted. This review compares MBVs to other types of extracellular vesicles to try and better understand their origin and function. Further, this review will explain various extracellular vesicle isolation methods and how these can be used for MBVs and summarize characterization of MBV cargo such as microRNA, proteins, and lipids. Lastly, we will summarize the effects of MBVs on cells. MBVs are a novel class of extracellular vesicles that hold great promise as a platform for delivery of targeted gene and drug therapeutics.

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来源期刊
Cells Tissues Organs
Cells Tissues Organs 生物-发育生物学
CiteScore
4.90
自引率
3.70%
发文量
45
审稿时长
6-12 weeks
期刊介绍: ''Cells Tissues Organs'' aims at bridging the gap between cell biology and developmental biology and the emerging fields of regenerative medicine (stem cell biology, tissue engineering, artificial organs, in vitro systems and transplantation biology). CTO offers a rapid and fair peer-review and exquisite reproduction quality. Special topic issues, entire issues of the journal devoted to a single research topic within the range of interests of the journal, are published at irregular intervals.
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