非甾体抗炎药在病毒感染疾病中的应用,特别是 COVID-19。

Advanced Biomedical Research Pub Date : 2023-01-30 eCollection Date: 2023-01-01 DOI:10.4103/abr.abr_148_21
Narges Chamkouri, Forouzan Absalan, Zahra Koolivand, Mahsa Yousefi
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引用次数: 0

摘要

在当前的 SARS-CoV-2(COVID-19)大流行期间,有一些报道称非甾体抗炎药(NSAIDs)和皮质类固醇可能会加重 COVID-19 患者的症状。有鉴于此,我们旨在整理已发表文章中的信息,找出这些说法背后的证据,以帮助临床医生找到治疗患者的最佳方法。我们未能找到公开发表的支持或反对在 COVID-19 患者中使用非甾体抗炎药的确凿证据。同时,似乎有一些证据表明,如果在感染的早期急性期使用皮质类固醇,可能会有好处,但是,世界卫生组织(WHO)关于在某些病毒感染中使用皮质类固醇的证据相互矛盾,这意味着该证据并不具有决定性。鉴于目前已有的文献,在出现更多关于在 COVID-19 患者中使用非甾体抗炎药和皮质类固醇的证据之前,应谨慎行事。不过,为临床医生和患者提供可靠的信息至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nonsteroidal Anti-Inflammatory Drugs in Viral Infections Disease, Specially COVID-19.

During the current SARS-CoV-2 (COVID-19) pandemic, some reports were presented based on those nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. According to this, we aimed to collate information available in published articles to identify any evidence behind these statements with the aim of helping clinicians on how best to treat patients. We could not find published conclusive evidence for or against the use of NSAIDs in COVID-19 patients. Meanwhile, there appeared to be some evidence that corticosteroids may be beneficial if utilized in the early acute phase of infection, however, conflicting WHO (World Health Organization) evidence surrounding corticosteroid use in certain viral infections means this evidence is not conclusive. Given the current availability of literature, caution should be exercised until further evidence emerges surrounding the use of NSAIDs and corticosteroids in COVID-19 patients. However, the availability of reliable information for clinicians and patients is paramount.

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