[多酚是有前途的生物活性化合物]。

Q2 Medicine
T N Bobrysheva, G S Anisimov, M S Zolotoreva, D V Bobryshev, R O Budkevich, A A Moskalev
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引用次数: 0

摘要

多酚是种类繁多、分布广泛的植物性生物活性化合物。这些化合物存在于各种食物中,如浆果、水果、蔬菜、谷物、坚果、咖啡、可可、香料、种子。它们根据分子结构分为酚酸类、二苯乙烯类、类黄酮类和木脂素类。它们对人体具有广泛的生物学作用,引起了研究人员的广泛关注。这项工作的目的是分析现代科学出版物对多酚的生物效应。材料和方法。该综述基于PubMed、Google Scholar、ResearchGate、Elsevier、eLIBRARY、Cyberleninka数据库中发表的出版物,以“多酚”、“类黄酮”、“白藜芦醇”、“槲皮素”、“儿茶素”为关键词。优先考虑过去10年在评审期刊上发表的原创研究。结果。氧化应激、慢性炎症、微生物组紊乱、胰岛素抵抗、过度蛋白糖基化和基因毒性作用是许多疾病发病机制的核心,包括那些与年龄相关的疾病。关于多酚的抗氧化、抗癌、表观遗传、代谢、保老、抗炎、抗病毒等作用已经积累了大量的资料。这使我们有理由认为多酚是一种非常有前途的微量营养素,在饮食中加入多酚可以减少患心血管、肿瘤、神经退行性疾病、糖尿病、肥胖、代谢综合征、过早衰老的风险,这些疾病是现代人死亡的主要原因,寿命和生活质量下降。结论。扩大富含高生物利用度的多酚的产品范围是科学研究和生产开发的一个有前途的领域,以预防具有社会意义的与年龄相关的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Polyphenols as promising bioactive compounds].

Polyphenols are diverse and widespread bioactive plant-based compounds. These compounds are found in various foods such as berries, fruits, vegetables, cereals, nuts, coffee, cacao, spices, seeds. They are divided into phenolic acids, stilbenes, flavonoids, lignans depending on their molecular structure. They attract the attention of researchers due to wide range of biological effects on human body. The purpose of this work was to analyze modern scientific publications on the biological effects of polyphenols. Material and methods. The review is based on publications presented in the PubMed, Google Scholar, ResearchGate, Elsevier, eLIBRARY, Cyberleninka databases using "polyphenols", "flavonoids", "resveratrol", "quercetin", "catechins" as key words. Preference was given to original researches over the past 10 years published in refereed journals. Results. Oxidative stress, chronic inflammation, microbiome disorders, insulin resistance, excessive protein glycation, and genotoxic effects are at the heart of the pathogenesis of many diseases, including those associated with age. A large amount of material has been accumulated on the antioxidant, anticarcinogenic, epigenetic, metabolic, geroprotective, anti-inflammatory and antiviral effects of polyphenols. This gives reasons to consider polyphenols as very promising micronutrients, which inclusion in the diet can reduce the risk of developing cardiovascular, oncological, neurodegenerative diseases, diabetes mellitus, obesity, metabolic syndrome, premature aging, that is, the main causes of death, a decrease in the duration and quality of life of a modern person. Conclusion. Expanding the range of products enriched with polyphenols with their high bioavailability is a promising area of scientific research and development of production in order to prevent socially significant age-associated diseases.

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来源期刊
Voprosy pitaniia
Voprosy pitaniia Medicine-Medicine (all)
CiteScore
2.00
自引率
0.00%
发文量
46
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