Rafael Campos Arjona, Fernando Carrasco Chinchilla, Alberto López Blázquez, Juan Horacio Alonso Briales, Antonio Jesús Muñoz García, Antonio Domínguez Franco, Manuel Jiménez Navarro, Jose María Hernández García, Eduardo de Teresa Galván
{"title":"二尖瓣反流病因对MitraClip®治疗患者晚期死亡率的影响","authors":"Rafael Campos Arjona, Fernando Carrasco Chinchilla, Alberto López Blázquez, Juan Horacio Alonso Briales, Antonio Jesús Muñoz García, Antonio Domínguez Franco, Manuel Jiménez Navarro, Jose María Hernández García, Eduardo de Teresa Galván","doi":"10.1016/j.carcor.2018.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Mitral regurgitation is the second most common cause of valvular heart disease, and even though it involves so bad prognosis, almost a half of patients are rejected from surgical treatment. For this cohort of patients, it has treated with MitraClip<sup>®</sup> with promising outcomes in both functional and degenerative etiology of mitral regurgitation.</p></div><div><h3>Material and methods</h3><p>Retrosprective observational study about features and outcomes of 72 patients underwent MitraClip<sup>®</sup> implantation from November 2011 to October 2016.</p></div><div><h3>Results</h3><p>Mitral regurgitation etiology was functional (61.1%), degenerative (26.4%) or mixed (12.5%). The functional etiology was associated with lower age (67.9<!--> <!-->±<!--> <!-->8.74 vs 74.6<!--> <!-->±<!--> <!-->13.06 years old, <em>P</em> <!-->=<!--> <!-->.21) and lower left ventricular ejection fraction (34<!--> <!-->±<!--> <!-->8.5% vs 57<!--> <!-->±<!--> <!-->15%; <em>P</em> <!--><<!--> <!-->.001). The median EuroSCORE-II was 3.84 (Q1-Q3 quartile: 2.21-8.10). There was no differences about the number of clips used (1.55<!--> <!-->±<!--> <!-->0.68 functional and 1.64<!--> <!-->±<!--> <!-->0.55 degenerative, <em>P</em> <!-->=<!--> <!-->.53) or the number of days in hospitalary admission after intervention (3.36 functional vs 3.7 degenerative; p<!--> <!-->=<!--> <!-->.56). Regurgitation reduction was partial (more than grade 2) in 4.5% of functional etiology and 14.3% of degenerative etiology (<em>P</em> <!-->=<!--> <!-->.145). No cases of in-hospital mortality or during the first month after discharge were reported. During an average follow up of 24 months it was reported 9 deaths (20.45%) in functional etiology and 2 deaths (7.14%) in degenerative/mixed etiology (<em>P</em> <!-->=<!--> <!-->.13).</p></div><div><h3>Conclusion</h3><p>MitraClip® treatment is safe and effective in patients with both functional and degenerative etiology of mitral regugitation, even though the last one seems to be associated with a lower late mortality rate.</p></div>","PeriodicalId":100216,"journal":{"name":"Cardiocore","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impacto de la etiología de la regurgitación mitral en la mortalidad tardía de pacientes tratados con MitraClip®\",\"authors\":\"Rafael Campos Arjona, Fernando Carrasco Chinchilla, Alberto López Blázquez, Juan Horacio Alonso Briales, Antonio Jesús Muñoz García, Antonio Domínguez Franco, Manuel Jiménez Navarro, Jose María Hernández García, Eduardo de Teresa Galván\",\"doi\":\"10.1016/j.carcor.2018.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Mitral regurgitation is the second most common cause of valvular heart disease, and even though it involves so bad prognosis, almost a half of patients are rejected from surgical treatment. For this cohort of patients, it has treated with MitraClip<sup>®</sup> with promising outcomes in both functional and degenerative etiology of mitral regurgitation.</p></div><div><h3>Material and methods</h3><p>Retrosprective observational study about features and outcomes of 72 patients underwent MitraClip<sup>®</sup> implantation from November 2011 to October 2016.</p></div><div><h3>Results</h3><p>Mitral regurgitation etiology was functional (61.1%), degenerative (26.4%) or mixed (12.5%). The functional etiology was associated with lower age (67.9<!--> <!-->±<!--> <!-->8.74 vs 74.6<!--> <!-->±<!--> <!-->13.06 years old, <em>P</em> <!-->=<!--> <!-->.21) and lower left ventricular ejection fraction (34<!--> <!-->±<!--> <!-->8.5% vs 57<!--> <!-->±<!--> <!-->15%; <em>P</em> <!--><<!--> <!-->.001). The median EuroSCORE-II was 3.84 (Q1-Q3 quartile: 2.21-8.10). There was no differences about the number of clips used (1.55<!--> <!-->±<!--> <!-->0.68 functional and 1.64<!--> <!-->±<!--> <!-->0.55 degenerative, <em>P</em> <!-->=<!--> <!-->.53) or the number of days in hospitalary admission after intervention (3.36 functional vs 3.7 degenerative; p<!--> <!-->=<!--> <!-->.56). Regurgitation reduction was partial (more than grade 2) in 4.5% of functional etiology and 14.3% of degenerative etiology (<em>P</em> <!-->=<!--> <!-->.145). No cases of in-hospital mortality or during the first month after discharge were reported. During an average follow up of 24 months it was reported 9 deaths (20.45%) in functional etiology and 2 deaths (7.14%) in degenerative/mixed etiology (<em>P</em> <!-->=<!--> <!-->.13).</p></div><div><h3>Conclusion</h3><p>MitraClip® treatment is safe and effective in patients with both functional and degenerative etiology of mitral regugitation, even though the last one seems to be associated with a lower late mortality rate.</p></div>\",\"PeriodicalId\":100216,\"journal\":{\"name\":\"Cardiocore\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiocore\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1889898X18300082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiocore","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1889898X18300082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impacto de la etiología de la regurgitación mitral en la mortalidad tardía de pacientes tratados con MitraClip®
Introduction
Mitral regurgitation is the second most common cause of valvular heart disease, and even though it involves so bad prognosis, almost a half of patients are rejected from surgical treatment. For this cohort of patients, it has treated with MitraClip® with promising outcomes in both functional and degenerative etiology of mitral regurgitation.
Material and methods
Retrosprective observational study about features and outcomes of 72 patients underwent MitraClip® implantation from November 2011 to October 2016.
Results
Mitral regurgitation etiology was functional (61.1%), degenerative (26.4%) or mixed (12.5%). The functional etiology was associated with lower age (67.9 ± 8.74 vs 74.6 ± 13.06 years old, P = .21) and lower left ventricular ejection fraction (34 ± 8.5% vs 57 ± 15%; P < .001). The median EuroSCORE-II was 3.84 (Q1-Q3 quartile: 2.21-8.10). There was no differences about the number of clips used (1.55 ± 0.68 functional and 1.64 ± 0.55 degenerative, P = .53) or the number of days in hospitalary admission after intervention (3.36 functional vs 3.7 degenerative; p = .56). Regurgitation reduction was partial (more than grade 2) in 4.5% of functional etiology and 14.3% of degenerative etiology (P = .145). No cases of in-hospital mortality or during the first month after discharge were reported. During an average follow up of 24 months it was reported 9 deaths (20.45%) in functional etiology and 2 deaths (7.14%) in degenerative/mixed etiology (P = .13).
Conclusion
MitraClip® treatment is safe and effective in patients with both functional and degenerative etiology of mitral regugitation, even though the last one seems to be associated with a lower late mortality rate.