二尖瓣反流病因对MitraClip®治疗患者晚期死亡率的影响

Rafael Campos Arjona, Fernando Carrasco Chinchilla, Alberto López Blázquez, Juan Horacio Alonso Briales, Antonio Jesús Muñoz García, Antonio Domínguez Franco, Manuel Jiménez Navarro, Jose María Hernández García, Eduardo de Teresa Galván
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引用次数: 0

摘要

二尖瓣反流是瓣膜性心脏病的第二大常见原因,尽管预后很差,但几乎有一半的患者拒绝接受手术治疗。对于这组患者,使用MitraClip®治疗二尖瓣反流在功能性和退行性病因方面都有很好的结果。材料与方法回顾性观察2011年11月至2016年10月行MitraClip®植入的72例患者的特点及结局。结果二尖瓣反流病因为功能性(61.1%)、退行性(26.4%)和混合性(12.5%)。功能病因学与较低的年龄(67.9±8.74岁vs 74.6±13.06岁,P = 0.21)和较低的左室射血分数(34±8.5% vs 57±15%;P & lt;措施)。EuroSCORE-II的中位数为3.84 (Q1-Q3四分位数:2.21-8.10)。在使用夹子的数量(1.55±0.68个功能性夹子和1.64±0.55个退行性夹子,P = 0.53)或干预后住院天数(3.36个功能性夹子vs 3.7个退行性夹子;p = .56)。在4.5%的功能性病因和14.3%的退行性病因中,返流减少是部分的(超过2级)(P = 0.145)。无院内死亡病例或出院后第一个月内死亡病例报告。在平均24个月的随访中,功能性病因死亡9例(20.45%),退行性/混合病因死亡2例(7.14%)(P = 0.13)。结论mitraclip®治疗对于二尖瓣功能调节和退行性二尖瓣调节的患者是安全有效的,尽管后者似乎与较低的晚期死亡率相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impacto de la etiología de la regurgitación mitral en la mortalidad tardía de pacientes tratados con MitraClip®

Introduction

Mitral regurgitation is the second most common cause of valvular heart disease, and even though it involves so bad prognosis, almost a half of patients are rejected from surgical treatment. For this cohort of patients, it has treated with MitraClip® with promising outcomes in both functional and degenerative etiology of mitral regurgitation.

Material and methods

Retrosprective observational study about features and outcomes of 72 patients underwent MitraClip® implantation from November 2011 to October 2016.

Results

Mitral regurgitation etiology was functional (61.1%), degenerative (26.4%) or mixed (12.5%). The functional etiology was associated with lower age (67.9 ± 8.74 vs 74.6 ± 13.06 years old, P = .21) and lower left ventricular ejection fraction (34 ± 8.5% vs 57 ± 15%; P < .001). The median EuroSCORE-II was 3.84 (Q1-Q3 quartile: 2.21-8.10). There was no differences about the number of clips used (1.55 ± 0.68 functional and 1.64 ± 0.55 degenerative, P = .53) or the number of days in hospitalary admission after intervention (3.36 functional vs 3.7 degenerative; p = .56). Regurgitation reduction was partial (more than grade 2) in 4.5% of functional etiology and 14.3% of degenerative etiology (P = .145). No cases of in-hospital mortality or during the first month after discharge were reported. During an average follow up of 24 months it was reported 9 deaths (20.45%) in functional etiology and 2 deaths (7.14%) in degenerative/mixed etiology (P = .13).

Conclusion

MitraClip® treatment is safe and effective in patients with both functional and degenerative etiology of mitral regugitation, even though the last one seems to be associated with a lower late mortality rate.

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