五棱藤(Meliaceae)茎皮中的哈瓦那素型柠檬素

IF 0.5 Q4 MULTIDISCIPLINARY SCIENCES

Journal of Mathematical and Fundamental Sciences Pub Date : 2023-05-15 DOI:10.5614/j.math.fund.sci.2022.54.3.2

U. Supratman, Dudi Runadi, Purnama Purnama, S. Salam, Nulelasari Nurlelasari, D. Harneti, T. Mayanti, R. Maharani, Y. Shiono

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引用次数: 0

摘要

在Chisocheton pentandrus茎皮中发现了一种新的类柠檬素，称为pentandricine E(1)，与其他四种已知类型，即醋酸三烯酮(2)，toonaciliatones C (3)， 11α-acetoxyazadirone(4)和ceramicine I(5)一起属于havanenin型。分离得到的1 ~ 5个化合物的结构通过NMR和HRTOFMS进行了鉴定。Pentandricine E(1)对MCF-7乳腺癌细胞系的细胞毒性最高，IC50值为63.27±0.21 mM。

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Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)

A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.

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来源期刊

Journal of Mathematical and Fundamental Sciences MULTIDISCIPLINARY SCIENCES-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： Journal of Mathematical and Fundamental Sciences welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health Sciences, Medical Sciences, Pharmacy), Mathematics, Physics, and Statistics. New submissions of mathematics articles starting in January 2020 are required to focus on applied mathematics with real relevance to the field of natural sciences. Authors are invited to submit articles that have not been published previously and are not under consideration elsewhere.