脑脊液的机械过滤:程序、系统和应用。

IF 2.9 3区 医学 Q3 ENGINEERING, BIOMEDICAL
Manuel Menéndez González
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引用次数: 2

摘要

导论:针对脑脊液(CSF)过滤的机械方法是一组已被提出用于治疗脑脊液中存在病原体的神经系统疾病的疗法。尽管医疗器械行业在这一领域并不十分活跃,但缺乏可应用的不同系统和程序的系统化。涵盖的领域:首先,我们将CSF机械过滤的程序和系统的分类和定义系统化。然后,我们进行了文献综述,寻找任何提出或应用机械CSF清除系统的临床或临床前研究。专家意见:我们在蛛网膜下腔出血、中枢神经系统感染(细菌、病毒和真菌)、脑膜癌病、多发性硬化症、自身免疫性脑炎和多根脊髓炎中发现脑脊液的机械滤过。脑老化和神经退行性疾病是额外的潜在的兴趣条件。虽然这些疾病中有一些初步的积极证据,但要在未来几十年使这些疗法成为现实,还需要更先进的系统、详细的程序描述和严格的验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanical filtration of the cerebrospinal fluid: procedures, systems, and applications.

Introduction: Mechanical methods aimed at the filtration of the cerebrospinal fluid (CSF) are a group of therapies that have been proposed to treat neurological conditions where pathogens are present in the CSF. Even though the industry of medical devices has not been very active in this field, there is a lack of systematization of the different systems and procedures that can be applied.

Areas covered: First, we systematize the classification and definitions of procedures and systems for mechanical filtration of the CSF. Then, we made a literature review in search of clinical or preclinical studies where any system of mechanical CSF clearance was proposed or applied.

Expert opinion: We found mechanical filtration of the CSF has been explored in subarachnoid hemorrhage, CNS infections (bacterial, viral, and fungal), meningeal carcinomatosis, multiple sclerosis, autoimmune encephalitis, and polyradiculomyelitis. Brain aging and neurodegenerative diseases are additional potential conditions of interest. While there is some preliminary positive evidence for many of these conditions, more advanced systems, detailed descriptions of procedures, and rigorous validations are needed to make these therapies a reality in the next decades.

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来源期刊
Expert Review of Medical Devices
Expert Review of Medical Devices 医学-工程:生物医学
CiteScore
5.90
自引率
3.20%
发文量
69
审稿时长
6-12 weeks
期刊介绍: The journal serves the device research community by providing a comprehensive body of high-quality information from leading experts, all subject to rigorous peer review. The Expert Review format is specially structured to optimize the value of the information to reader. Comprehensive coverage by each author in a key area of research or clinical practice is augmented by the following sections: Expert commentary - a personal view on the most effective or promising strategies Five-year view - a clear perspective of future prospects within a realistic timescale Key issues - an executive summary cutting to the author''s most critical points In addition to the Review program, each issue also features Medical Device Profiles - objective assessments of specific devices in development or clinical use to help inform clinical practice. There are also Perspectives - overviews highlighting areas of current debate and controversy, together with reports from the conference scene and invited Editorials.
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