M. Abdelhalim, Y. M. H. Salaheldeen, O. Idris., E. Abdelsalam, M. Sabahelkhier.
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Histopathological Effect on Different Rat Tissues Induced By the Trihalomethane-Bromoform Administered In Drinking Water
Introduction: The experiment was designed to investigate the histopathological changes in rat’s tissues due to the effect of the trihalomethane (THM) -bromoform when administered in drinking water. Methods: A group of male Wistar rat was exposed to trihalomethane-bromoform (TBM) at concentration 750 ppm in their drinking water and dose 38.72 mg/kg per day for a month. Results: The growth rate and food intake were not affected by treatment, but TBM reduced significantly water consumption. Conclusions: This study demonstrate that, the brominated THM-bromoform administered in the drinking water induced cancer to the liver and caused hyperplasia to the urinary bladder beside the nephrotoxicity and the toxicity in small intestine demonstrated in the current study.
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