ACE2 PET对宿主兔冠状病毒疫苗接种后应答的功能观察。

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiao Li, Jie Li, Pan Zhou, Danni Li, Mingxin Wang, Qianqian Tong, Jian Chen, Changjing Zuo, Lan Zhang, Rou Li
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引用次数: 0

摘要

分子成像可以动态、定量地记录系统的生化变化。本研究采用肌内注射SARS-CoV-2假病毒,模拟灭活病毒疫苗接种。采用18F-FDG PET和68Ga-cyc-DX600 PET分别于注射前、注射后3、7、14天(d P.I.)检测新西兰大白兔的炎症反应和ACE2波动情况;每只兔接种2个周期,间隔14 d,进行较长时间的评价。不同于疫苗诱导的炎症反应的随机性和个别性,ACE2的调节具有全体性和器官特异性:肝脏和脾脏在注射后出现中度下降,但在注射后第14天出现反弹,而心脏、睾丸和骨髓则有下降趋势;此外,第二次注射后ACE2的调节模式相似,但波动性相对较大。综上所述,ACE2 PET能够更全面地了解疫苗接种后的宿主反应,在冠状病毒疫苗给药和有效性的持续监测中具有重要的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The functional views on response of host rabbit post coronavirus vaccination via ACE2 PET.

Molecular imaging can dynamically and quantitatively record the biochemical changes in a systemic view. In this research, SARS-CoV-2 pseudovirus was intramuscularly injected to simulate the vaccination with inactivated virus. New Zealand white rabbits were evaluated with 18F-FDG PET for inflammation and 68Ga-cyc-DX600 PET for ACE2 fluctuation, which were performed before and at 3, 7 and 14 days post injection (d P.I.); furthermore, one rabbit was vaccinated with two cycles with interval of 14 days for a longer period evaluation. Different with the vaccination-induced inflammatory response that was random and individual, ACE2 regulation was systemic and organ-specific: the liver and spleen were of a moderate decrease post injection but rebound at 14 d P.I., while there were a downward trend in heart, testis and bone marrow; besides, similar pattern of ACE2 regulation were recorded after the second injection with a relatively greater volatility. In conclusion, ACE2 PET gave a more comprehensive view on host response post vaccination, hold substantial promise in continuous monitoring of coronavirus vaccine administration and effectiveness.

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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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