圆锥角膜患者角膜胶原交联前后角膜密度测定

Alaraby Abd Elghany Nassar, Mohamed AlTaher Wahab, M. Abou Ahmed
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摘要

圆锥角膜是一种扩张性角膜疾病,其特征是角膜逐渐变薄,导致角膜突出、不规则散光和视力下降。目的探讨角膜锥形患者角膜交联(CXL)术后角膜密度的变化。患者和方法这是一项前瞻性病例系列研究,包括所有接受CXL的圆锥角膜患者(50只眼)。本研究男性患者13例(26眼),女性患者12例(24眼);该研究在爱资哈尔大学医院眼科门诊进行。结果术前角膜密度测定与K1、K2、K-max、最薄角膜厚度无统计学意义。术后1个月角膜密度测定与K1、K2、K-max或最薄角膜厚度无统计学意义。术后3个月角膜密度测定与K1、K-max或最薄角膜厚度之间无统计学意义的相关性。由表可知,角膜密度与K2之间存在显著正相关,P值为0.037,r=0.296。术后6个月角膜密度测定与K1、K2、K-max或最薄角膜厚度之间无统计学意义的相关性。结论CXL术后,Scheimpflug角膜密度测定和临床角膜混浊在术后1个月达到峰值,6个月逐渐下降至基线。术后1个月角膜变薄与角膜浑浊呈负相关。晶体密度测定不受CXL的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Corneal densitometry before and after corneal collagen cross-linking in patients with keratoconus
Background Keratoconus is an ectatic corneal disorder characterized by progressive corneal thinning that results in corneal protrusion, irregular astigmatism, and decreased vision. Objective To evaluate changes in corneal density following corneal cross-linking (CXL) in keratoconic patients. Patients and methods This was a prospective case series study including all patients with keratoconus (50 eyes) undergoing CXL. The number of male patients in the study was 13 (26 eyes) cases, while female patients represented 12 (24 eyes) cases; the study was conducted at the outpatient clinic of the Ophthalmology Department at Al Azhar University Hospital. Results There was no statistically significant correlation between corneal densitometry and K1, K2, K-max, or thinnest corneal thickness preoperatively. There was no statistically significant correlation between corneal densitometry and K1, K2, K-max or thinnest corneal thickness at 1 month postoperatively. There was no statistically significant correlation between corneal densitometry and K1, K-max, or thinnest corneal thickness at 3 months postoperatively. Also, the table shows that there was statistically significant positive correlation between corneal densitometry and K2 with P value of 0.037 and r=0.296. There was no statistically significant correlation between corneal densitometry and K1, K2, K-max, or thinnest corneal thickness at 6 months postoperatively. Conclusion After CXL, the Scheimpflug corneal densitometry and clinical corneal haze peaked at 1 month followed by a gradual decline reaching baseline by 6 months after operation. Corneal thinning was correlated inversely with the corneal haze at 1 month postoperatively. Lens densitometry was not affected by CXL.
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