Pharmacogenic and neurologic components of residual condition in schizophrenia

Aim. To systematize neuroleptic-induced and neurologic components of residual condition in schizophrenia. Materials and methods. 100 patients of Communal Non-Profit Enterprise “Regional Clinical Institution for the Provision of Psychiatric Care” of Zaporizhzhia Regional Council with diagnosis of recurrent schizophrenia (ICD-10: F20.5) were examined. Results. The study has found correlations between pharmacotherapy and cerebrovascular pathology with positive and negative symptoms of residual schizophrenia. Noticeable positive correlations were established between specific antipsychotic prescriptions and positive negative schizophrenia symptoms, while only minor correlations with negative symptoms were found. Analysis of cerebrovascular pathology with positive and negative symptoms showed that most noticeable positive correlations were anterior area stroke with hallucinations. Overall dominance of negative correlations over positive ones showed possible trend of “forced normalization” caused by cerebrovascular pathology of schizophrenia manifestations in recurrent condition, which was, however, also minor. Conclusions. The study has found correlations between pharmacotherapy and cerebrovascular pathology with positive and negative symptoms of residual schizophrenia. The concept of “antipsychotic course experience” was introduced.