用于肿瘤和社会原因的卵母细胞玻璃化。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nadiye Köroğlu, Turgut Aydın
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引用次数: 0

摘要

本综述的目的是提供有关卵母细胞冷冻保存的信息,特别是卵母细胞玻璃化,用于保存肿瘤和社会适应症的生育能力。卵母细胞冷冻保存的成功率随着玻璃化技术的广泛使用而增加,目前与用新鲜卵母细胞进行体外受精的成功率相似。玻璃化是最成功的卵母细胞冷冻保存技术。影响成功率的最重要因素是患者玻璃化时的年龄和冷冻成熟卵母细胞的数量。因此,每个年龄的活产率取决于解冻卵母细胞的数量和冷冻方法。美国生殖医学学会和美国临床肿瘤学会建议在癌症患者中采用卵母细胞冷冻保存来保存生育能力。除了癌症患者外,随着冷冻保存技术的发展以及与使用新鲜卵母细胞相似的妊娠率的实现,希望推迟怀孕年龄和生育自由的女性越来越多地使用卵母细胞玻璃化。为患者提供适应证、年龄成功率、冷冻卵母细胞总数等咨询服务。应该强调的是,这一程序并不是生育的保险政策,特别是在选择性卵母细胞冷冻保存中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oocyte vitrification for oncological and social reasons.

The aim of this review is to present information related to oocyte cryopreservation, and particularly oocyte vitrification, performed to preserve fertility in oncologic and social indications. The success rates of oocyte cryopreservation have increased with the widespread use of the vitrification technique and are currently similar to those of in vitro fertilization performed with fresh oocytes. Vitrification is the most successful technique for oocyte cryopreservation. The most important factors that influence the success rate are the patient's age at the time of vitrification and the number of mature oocytes frozen. Thus, live birth rates differ for each age depending on the number of oocytes thawed and the freezing method. The American Society of Reproductive Medicine and the American Society of Clinical Oncology recommend presenting the option of oocyte cryopreservation for fertility preservation in cancer patients. Besides cancer patients, use of oocyte vitrification is increasing in women who wish to postpone pregnancy age and to have reproductive freedom with the development of the cryopreservation technique and the achievement of pregnancy rates similar to the use of fresh oocytes. Patients are provided consultancy service in terms of indication, the success rates by age, and the total number of oocytes frozen. It should be emphasized that this procedure is not a type of insurance policy for fertility, especially in elective oocyte cryopreservation.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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