市售Embelia种(Vidanga)样品药典特性的验证

Shreshtha Kaushik
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引用次数: 2

摘要

简介:Embelia ribes Burm。紫薇科是一种很有前途的草药,自吠陀时期以来,它具有消化、通便、驱虫药和泻药的特性。由于其过度采收,在红色名录数据手册中被报告为脆弱物种。因此,在市场上,由于其与ribes在形态上的密切相似性,通常会发现与robusta掺杂。因此,本研究试图验证和比较两种维丹加(E. ribes)和罗布斯塔(E. robusta)果实的理化参数和色谱特征,以正确识别干燥形式的药物并检查掺假。材料与方法:按照标准对两种维丹加(E. ribes)和罗布斯塔(E. robusta)果实进行宏观性状、感官、干燥损失、总灰分、酸不溶灰分、水溶性灰分、醇、水溶性提取物等理化参数评价和高效薄层色谱(HPTLC)分析。结果:宏观研究切片显示,这两个物种的果实在颜色,大小和喙的存在,如突出和膜在果皮上。E. ribes的独特特征是其种子(Chitratandula)上存在白色斑点,这在罗布斯塔种子中是不存在的。所有理化指标均符合印度《阿育吠陀药典》规定的标准。这些发现完成了验证药典特征的主要目的。此外,我们观察到,除了一个参数,即水溶性提取物,两种植物的物理化学常数没有显著差异。此外,HPTLC提供了一些相同的Rf和一些不同的Rf。讨论:由于在常规的质量控制分析中没有观察到样品之间可能的植物和物理化学差异,因此得出结论,一尘不染的维丹加,即罗布斯塔也可以用于制药。此外,可以对来自不同市场来源的多个样本进行扩展研究,以在分析和治疗方面获得进一步的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Validation of pharmacopoeial characters of marketed samples of Embelia species (Vidanga)
Introduction: Embelia ribes Burm. f., Myrsinaceae is a promising medicinal herb valued for its digestive, carminative, anthelmintic, and laxative property since Vedic period. Due to its excessive harvesting, it is reported in red list data book as vulnerable. Hence, in markets, E. ribes is generally found adulterated with E. robusta due to its close morphological similarity with ribes. Thus, the present study attempts to validate and compare physicochemical parameters and chromatographic profile of fruits of two species of Vidanga, that is, E. ribes and E. robusta for proper identification of the drug in dry form and to check adulteration. Materials and Methods: Evaluation of macroscopic characters, physicochemical parameters such as organoleptic, loss on drying, total ash, acid insoluble ash, water soluble ash, alcohol, and water soluble extractives as well as high performance thin-layer chromatography (HPTLC) analysis were performed for fruits of both the species of Vidanga, namely, E. ribes and E. robusta as per standard guidelines. Results: The macroscopic study section revealed that the fruits of both the species vary in color, size, and presence of beak such as projection and membrane over the pericarp. The distinct character of E. ribes is the presence of whitish spots on its seeds (Chitratandula) which is found to be absent in robusta seeds. All the physicochemical parameters of E. ribes were found in compliance with the official standards laid down by Ayurvedic Pharmacopeia of India. These findings accomplished the chief objective of validating the pharmacopoeial characters. Moreover, it was observed that there are no significant differences in the physicochemical constants of both the species except one parameter, that is, water soluble extractives. Apart, HPTLC proffered some identical as well as some dissimilar Rf . Discussion: As no remarkable differences were observed in conventional quality control assays for possible phyto and physicochemical variations between the samples, it is concluded that the spotless vidanga, that is, E. robusta can also be utilized in pharmaceutics. Moreover, extended studies with multiple samples from different market sources can be carried out to generate further evidences on analytical and therapeutic ground.
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