银屑病免疫发病机制中的微生物群及其前益生菌和益生菌营养的前景

A. Pandey, G. Pandey, S. Pandey, B. Pandey
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引用次数: 3

摘要

牛皮癣是一种常见的自身免疫性炎症性疾病,其发病机制是由基本的遗传易感性和环境触发因素共同推进的。银屑病的炎症可能是先天免疫系统为恢复免疫稳态而针对病原体的努力。与宿主相比,异常菌群可以通过几倍基因库的剪切优势来抵抗清除努力。微生物通过靶向宿主免疫系统的分子损伤来解除基因表达调控。微生物群在自身免疫中的作用决定了微生物群稳态的建立并抑制宿主免疫反应作为一种治疗方法。饮食中的益生元和益生菌对预防和改善自身免疫性炎症疾病特别感兴趣,因为它们有可能促进健康的宿主-微生物群关系。合理饮食的目的是通过调节肠道环境和调节免疫系统来改善炎症和自身免疫机制的调节,以平衡友好和敌对微生物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis
Psoriasis is a common autoimmune inflammatory disease wherein pathogenesis is advanced by fundamental genetic predisposition/s in concert with environmental triggers. Inflammation in psoriasis may represent efforts of innate immune system to target pathogens for restoring immune homeostasis. Aberrant microbiota may resist elimination efforts by shear advantage of several fold gene pool as compared to the host. The microbes deregulate gene expression by the molecular insults targeting host immune system. Role of microbiota in autoimmunity dictates establishment of microbiome homeostasis and suppress host immune response; as a treatment approach. Dietary prebiotics and probiotics are of particular interest for prevention and amelioration of autoimmune inflammatory diseases, due to their potential to foster healthy host-microbiome relationship. The rational dietetics aims towards balancing friendly versus enemical microbes via manipulation of gut environment and modulation of immune system to improve regulation of inflammatory and autoimmune mechanisms.
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