用热光谱技术研究替格瑞洛与药用辅料的相容性。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI:10.1691/ph.2019.9070

Jing Zhao, Jinhai Shen, Meiyu Gan, Cui-xiang Huang, Qihua You

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引用次数: 0

摘要

采用差示扫描量热法研究替格瑞洛与甘露醇、磷酸三碱钙、羧甲基淀粉钠、羟丙基纤维素和硬脂酸镁等辅料的相容性。拉曼光谱和等温应力测试实验进一步证实了材料的相容性。结果表明，替格瑞洛与甘露醇、磷酸三碱钙、羧甲基淀粉钠、羟丙基纤维素和硬脂酸镁具有较高的相容性。

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Compatibility of ticagrelor with pharmaceutical excipients studied with thermal and spectroscopic techniques.

The compatibility between ticagrelor and selected excipients (mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate) was investigated by differential scanning calorimetry. The compatibility was further corroborated by Raman spectroscopy and isothermal stress testing experiments. These results revealed that ticagrelor has high compatibility with mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate.

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Die Pharmazie. Beihefte

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