Healing times in a clinical case with similar and simultaneous lesions of hand and foot

A curious case of contemporary skin lesion of hand and foot, showing the healing at the hand site versus worsening and inflammation at the foot after ten days, gives the occasion of analysing the different behaviour of the capillary circulation related to hydrostatic pressure (HP). In fact, HP at the foot, higher than at the hand, causes an increase of capillary pressure, accompanied by increase of transmicrovascular filtration while that arteriovenous pressure gradient is maintained; however, the accumulation of fluids is resisted by a number of edema safety factors that work in concert to limit edema formation (Lymphatic flow, decrease osmotic pressure, reduce the number of capillaries, myogenic constriction of arterioles, venous bulging). It seems evident that this complex balance may easily be broken by modern everyday life common events.