绿咖啡豆提取物减轻庆大霉素引起的大鼠急性肾毒性

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-01 DOI:10.37360/blacpma.22.21.2.16

A. Unis, Amany Abdelbary

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引用次数: 0

摘要

庆大霉素引起的急性肾毒性(GIAN)被认为是急性肾功能衰竭的重要原因之一。近年来，人们一直致力于将草药作为一种新的治疗药物来预防GIAN。因此，本研究旨在探讨绿咖啡豆提取物(GCBE)对大鼠GIAN的影响。本研究结果显示，与GIAN模型组相比，在诱导GIAN后口服GCBE 7天(每天腹腔注射庆大霉素7天)的大鼠组肾功能测试有显著改善。此外，与GIAN模型组相比，gcbe治疗组肾脏氧化应激标志物(肾丙二醛、肾超氧化物歧化酶)和肾脏组织病理学改变均有显著改善。这些结果表明，GCBE具有改善GIAN肾损害的潜在作用。

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Green coffee bean extract attenuates gentamicin induced acute nephrotoxicity in rats

Gentamicin induced acute nephrotoxicity (GIAN) is considered as one of the important causes of acute renal failure. In recent years’ great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of GIAN. Hence, the current study was designed to investigate the effect of green coffee bean extract (GCBE) on GIAN in rats. Results of the present study showed that rat groups that received oral GCBE for 7 days after induction of GIAN (by a daily intraperitoneal injection of gentamicin for 7days), reported a significant improvement in renal functions tests when compared to the GIAN model groups. Moreover, there was significant amelioration in renal oxidative stress markers (renal malondialdehyde, renal superoxide dismutase) and renal histopathological changes in the GCBE-treated groups when compared to GIAN model group. These results indicate that GCBE has a potential role in ameliorating renal damage involved in GIAN.

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.