壳聚糖/聚(乙烯基吡咯烷酮)纳米淀粉增强物体外伤口愈合应用

Q2 Materials Science

Polymer-Plastics Technology and Engineering Pub Date : 2018-09-22 DOI:10.1080/03602559.2017.1381255

R. Poonguzhali, S. K. Basha, V. S. Kumari

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引用次数: 30

摘要

摘要纳米淀粉作为一种廉价且环保的填料，被广泛用于制备生物相容性薄膜。采用溶液铸造法制备了生物纳米复合材料。TEM分析表明，纳米淀粉的平均粒径在20 ~ 40 nm之间。当纳米淀粉含量为1%时，CS/PVP基质的热稳定性和细胞活力得到了最好的提高。CPS生物纳米复合材料对金黄色葡萄球菌和铜绿假单胞菌的抗菌活性，以及CPS的屏障性能、溶胀性能和更好的血液相容性等协同效应，使其成为体外伤口愈合材料的理想选择。图形抽象

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Nanostarch Reinforced with Chitosan/Poly (vinyl pyrrolidone) Blend for In Vitro Wound Healing Application

ABSTRACT Nanostarch, which is inexpensive and environmentally abundant, has been used as filler to prepare biocompatible films. The bio-nanocomposites were synthesized by solution casting method. TEM analysis proves that the average particle size of the nanostarch is in the range of 20–40 nm. Thermal stability and cell viability of CS/PVP matrix were best enhanced at 1% of nanostarch loading. The antibacterial activity exhibited by CPS bio-nanocomposite against Staphylococcus aureus and Pseudomonas aeruginosa and synergistic effects of CPS such as barrier properties, swelling properties, and better blood compatibility make it a suitable material for in vitro wound healing application. GRAPHICAL ABSTRACT

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来源期刊

Polymer-Plastics Technology and Engineering 工程技术-高分子科学

CiteScore

1.71

自引率

0.00%

发文量

审稿时长

4 months