去泛素化酶在快速高效细胞重编程中的应用前景

Journal of stem cell research & therapeutics Pub Date : 2017-06-08 DOI:10.15406/jsrt.2017.02.00083

Saba Haq, S. Ramakrishna

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引用次数: 0

摘要

缩写:DUB，去泛素化酶;胚胎干细胞;ICM，内细胞团;PTM，翻译后修饰;诱导多能干细胞;USP，泛素特异性加工蛋白酶;UCH，泛素羧基末端水解酶;OUT, o -结构域泛素醛结合蛋白;含jad1/pad/mpn结构域的金属酶;MCPIP，单核细胞趋化蛋白诱导蛋白酶;多能干细胞;CNS，中枢神经系统;CPP，细胞穿透肽;piPSCs，蛋白诱导多能干细胞;WWP2, www结构域含蛋白2;UPS，泛素蛋白酶体系统;mef，小鼠胚胎成纤维细胞;FBXW8, f-box/wd重复含蛋白8

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Future application of deubiquitylating enzymes for rapid and efficient cellular reprogramming

Abbreviations: DUB, deubiquitylating enzyme; ESCs, embryonic stem cells; ICM, inner cell mass; PTM, post-translational modification; iPSCs, induced pluripotent stem cells; USP, ubiquitin-specific processing protease; UCH, ubiquitin carboxy-terminal hydrolase; OUT, otu-domain ubiquitin aldehyde binding protein; JAMM, jad1/pad/mpn-domain-containing metalloenzyme; MCPIP, monocyte chemotactic protein-induced protease; PSC, pluripotent stem cell; CNS, central nervous system; CPP, cell penetrating peptide; piPSCs, protein-induced pluripotentstem cells; WWP2, ww domain-containing protein 2; UPS, ubiquitin proteasome system; MEFs, mouse embryonic fibroblasts; FBXW8, f-box/wd repeat-containing protein 8

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Journal of stem cell research & therapeutics

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