An unusual case of non-measurable glycosylated hemoglobin (HbA1c) by high-performance liquid chromatography in a type 2 diabetes

Diabetes is a chronic disease and to see the long-term glycemic control, most commonly glycosylated hemoglobin (HbA1c) is estimated. Presently, the most common method used to do HbA1c is high-performance liquid chromatography (HPLC) method. But in some cases unusually, low HbA1c is recorded by the HPLC method if hemoglobin variants are present. So in those cases, alternative methods of HbA1c estimation can be used to see the long-term glycemic status. So the presence of variants must be kept in mind and should be investigated properly so that when similar cases are encountered, it can be taken care appropriately.