宫颈功能不全妇女的激素和免疫学特征

D. Beglov, N. Artymuk, O. Novikova
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引用次数: 0

摘要

的目标。测定宫颈无力患者雌二醇、黄体酮、IgA和IgG对这些激素的水平,以及IgA/IgG对苯并[a]芘的水平。材料与方法。我们回顾性分析了200名妇女的病例史,包括100名在妊娠18-21周通过超声检查确定宫颈无力的患者和100名无宫颈无力的患者。采用酶联免疫吸附法测定妊娠18 ~ 21周小鼠血清雌二醇、孕酮、对这些激素的IgA、IgG和对苯并[a]芘的IgA/IgG。宫颈无力患者血清雌二醇水平较高[12477 (1000;31600) pg/mL], IgA对黄体酮[2.15 (0.6;8.3) a.u.]和苯并[a]芘[4.74 (0.4;13.9) a.u], IgG对雌二醇[8.64 (1.2;23.5) a.u.],黄体酮[5.29 (0.2;20.1) a.u.]和苯并[a]芘[11.89 (1.1;28.5 (a.u.)]与没有[10946 (2999;19480) pg/mL, p = 0.034];[1.42 (0.6;2.6) a.u., p = 0.034];[3.22 (0.7;5.7) a.u., p = 0.032];[4.78 (0.7;8.7) a.u., p < 0.0001];[2.55 (0.2;5.1) a.u., p < 0.0001];[4.72 (0.4;(1) a.u., p < 0.0001]。早产与IgA对孕酮(p = 0.00017)和苯并[a]芘(p = 0.0003)水平存在相关性。宫颈无力患者的特点是对雌二醇、黄体酮和苯并[a]芘的IgA和IgG水平较高;值得注意的是,IgA对孕酮和苯并[a]芘的增加与早产的高风险相关。
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Hormonal and immunological features of women with cervical insuffciency
Aim. To determine the level of estradiol, progesterone, IgA and IgG to these hormones, and IgA/IgG to benzo[a]pyrene in women with cervical weakness.Materials and Methods. We retrospectively analysed case histories of 200 women, including 100 patients with cervical weakness defned by an ultrasound examination at 18-21 weeks of gestation and 100 patients without cervical weakness. Serum estradiol, progesterone, IgA and IgG to these hormones, and IgA/IgG to benzo[a]pyrene were measured at 18-21 weeks of gestation using enzyme-linked immunosorbent assay.Results. Patients with cervical weakness had a higher level of serum estradiol [12477 (1000; 31600) pg/mL], IgA to progesterone [2.15 (0.6; 8.3) a.u.] and benzo[a]pyrene [4.74 (0.4; 13.9) a.u.], IgG to estradiol [8.64 (1.2; 23.5) a.u.], progesterone [5.29 (0.2; 20.1) a.u.], and benzo[a] pyrene [11.89 (1.1; 28.5) a.u.] as compared with those without [10946 (2999; 19480) pg/mL, p = 0.034]; [1.42 (0.6; 2.6) a.u., p = 0.034]; [3.22 (0.7; 5.7) a.u., p = 0.032]; [4.78 (0.7; 8.7) a.u., p < 0.0001]; [2.55 (0.2; 5.1) a.u., p < 0.0001]; [4.72 (0.4; 10.1) a.u., p < 0.0001]. An association between the preterm birth and levels of IgA to progesterone (p = 0.00017) and benzo[a]pyrene (p = 0.0003) was established.Conclusion. Patients with cervical weakness were characterized by higher levels of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene; notably, increased IgA to progesterone and benzo[a] pyrene correlated with a higher risk of preterm birth.
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