无机纳米颗粒概述:肿瘤治疗的扩展视野。

IF 2.5 4区 医学 Q3 ONCOLOGY
Lalit Kumar, Shivani Verma, Puneet Utreja, Dinesh Kumar
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引用次数: 2

摘要

背景:癌症的特征是人体中不受控制的细胞分裂破坏正常组织。迄今为止,研究了近100种癌症,这些癌症的传统治疗方法包括化疗、放射治疗和手术。传统方法存在药物分布不特异性、肿瘤内药物浓度低、心脏毒性等不良反应等缺点。因此,无机纳米颗粒在癌症治疗中得到了更好的应用。目的:综述无机纳米颗粒在肿瘤治疗中的作用,揭示其临床前研究现状及专利情况。方法:通过检索PubMed、Google Scholar、Google专利等多种搜索引擎进行文献调查。结果:无机纳米粒子是纳米医学在癌症治疗中探索的先进类别。无机纳米颗粒的结构特性使其成为靶向、成像和根除癌细胞的优秀候选者。此外,它们还具有较高的生物相容性和最小的全身毒性。结论:无机纳米颗粒可能是治疗癌症的更好选择。然而,它们在全球制药市场的存在将取决于新型放大技术的发展和临床评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overview of Inorganic Nanoparticles: An Expanding Horizon in Tumor Therapeutics.

Background: Cancer is characterized by uncontrolled cell division in the human body damaging normal tissues. There are almost a hundred types of cancers studied to date that are conventionally treated with chemotherapy, radiation therapy, and surgery. Conventional methods have drawbacks like non-specific distribution of drugs, low concentration of drugs in tumors, and adverse effects like cardiotoxicity. Therefore, inorganic nanoparticles are explored nowadays to achieve better results in cancer treatment.

Objective: The objective of this review paper was to summarize the role of inorganic nanoparticles in cancer treatment by revealing their preclinical status and patents.

Methods: Literature survey for the present work was conducted by exploring various search engines like PubMed, Google Scholar, and Google patents.

Results: Inorganic nanoparticles come under the advanced category of nanomedicine explored in cancer therapeutics. The structural properties of inorganic nanoparticles make them excellent candidates for targeting, imaging, and eradication of cancer cells. Besides this, they also show high biocompatibility and minimum systemic toxicity.

Conclusion: This review paper concludes that inorganic nanoparticles may be better alternatives to conventional approaches for the treatment of cancer. However, their presence in global pharmaceutical markets will be governed by the development of novel scale-up techniques and clinical evaluation.

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来源期刊
CiteScore
4.50
自引率
7.10%
发文量
55
审稿时长
3 months
期刊介绍: Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.
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