通过心脏磁共振成像诊断与免疫检查点抑制剂相关的心肌炎。

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2022-12-13 eCollection Date: 2023-04-01 DOI:10.1007/s13691-022-00588-1

Masafumi Fukumitsu, Ryo Ariyasu, Mitsutomi Ishiyama, Toshiaki Mochizuki, Koichi Takeda, Makiko Ono, Takuya Oyakawa, Aya Ebihara, Aya Nishizawa, Junichi Tomomatsu, Takahiro Kogawa, Shigehisa Kitano, Taro Shiga

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引用次数: 1

摘要

与免疫检查点抑制剂（ICIs）相关的心肌炎是一种罕见但严重的不良反应。虽然心内膜活检（EMB）是诊断心肌炎的标准，但由于取样错误和当地无法提供 EMB，可能会出现假阴性，这可能会妨碍心肌炎的正确诊断。因此，有人提出了基于心脏磁共振成像（CMRI）结合临床表现的替代标准，但未得到足够重视。我们报告了一例使用 ICIs 后的心肌炎病例，该病例为 48 岁男性，患有肺腺癌，通过 CMRI 诊断出心肌炎。CMRI 为诊断癌症治疗期间的心肌炎提供了机会。

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Myocarditis associated with immune-checkpoint inhibitors diagnosed by cardiac magnetic resonance imaging.

Myocarditis associated with immune-checkpoint inhibitors (ICIs) is a rare, but critical adverse event. Although endomyocardial biopsy (EMB) is the standard for diagnosis of myocarditis, there is a possibility of false negatives due to sampling errors and local nonavailability of EMB, which may hamper the appropriate diagnosis of myocarditis. Therefore, an alternative criterion based on cardiac magnetic resonance imaging (CMRI) combined with clinical presentation has been proposed, but not emphasized sufficiently. We report a case of myocarditis after ICIs administration, which was diagnosed using CMRI in a 48-year-old male with lung adenocarcinoma. CMRI provides an opportunity to diagnose myocarditis during cancer treatment.

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)