辣木和桂叶提取物自纳米乳化给药体系的制备与表征

PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCE, BIOTECHNOLOGY, AND BIOMETRICS 2019 Pub Date : 2019-12-23 DOI:10.1063/1.5141325

Suryani, W. Zubaydah, M. H. Sahumena, Siti Adawia, R. Wahyuni, Andi Nafisah Tendri Adjeng, Michrun Nisa, Henny Kasmawati, Sunandar Ihsan, Ruslin, M. Aswan

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引用次数: 6

摘要

植物作为传统药物的使用在印度尼西亚社会被广泛使用，特别是在仍然拥有大量植物品种的农村地区。经实证和研究具有潜在中药功效的植物是辣木油甙。辣木和决明子叶提取物。含有多种生物活性化合物，具有较高的抗氧化活性。然而，这些叶提取物的生物活性成分在水中的溶解度很低。因此，将其配制成自纳米乳化给药系统(SNEDDS)是提高提取物溶解度的解决方案之一。SNEDDS配方不仅提高了提取物的溶解度，而且提高了提取物的生物利用度，从而提高了治疗效果。结果表明，辣木提取物的sndds。和决明子。以玉米油为油相，吐温80为表面活性剂，丙二醇为助表面活性剂的提取物具有良好的纳米乳液性能。辣木和清明SNEDDS在人工胃液(AGF)培养基中的乳化时间分别为17 ~ 48秒和7 ~ 19秒;%透光率分别为89.40 ~ 90.09%和84.85 ~ 88.30%;最佳配方的粒径分别为10.7 nm和20.2 nm;多分散指数分别为0.012和0.447;zeta电位值分别为-5.0 mV和-3.9 mV。可以得出结论:辣木属植物。决明子叶提取物可配制成SNEDDS。植物作为传统药物的使用在印度尼西亚社会被广泛使用，特别是在仍然拥有大量植物品种的农村地区。经实证和研究具有潜在中药功效的植物是辣木油甙。辣木和决明子叶提取物。含有多种生物活性化合物，具有较高的抗氧化活性。然而，这些叶提取物的生物活性成分在水中的溶解度很低。因此，将其配制成自纳米乳化给药系统(SNEDDS)是提高提取物溶解度的解决方案之一。SNEDDS配方不仅提高了提取物的溶解度，而且提高了提取物的生物利用度，从而提高了治疗效果。结果表明，辣木提取物的sndds。和决明子。以玉米油为油相，吐温80为表面活性剂，丙二醇为助表面活性剂的提取物具有良好的纳米乳液性能。

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Preparation and characterization of self-nanoemulsifying drug delivery system (SNEDDS) from Moringa oleifera L.and Cassia alata L. leaves extracts

The use of plants as traditional medicine is widely used in Indonesia society, especially in rural areas that still have plenty of plant varieties. The plants that have been used empirically and investigated to have potential efficacy as traditional medicine are MoringaoleiferaL.andCassia alata L. Leaves Extracts of Moringaoleifera L and Cassia alataL. contain several bioactive compounds and have high antioxidant activity. However, bioactive compounds of those leaves extract have low solubility in water. Hence, to be formulated into Self-Nanoemulsifying Drug Delivery System (SNEDDS) is one of the solutions to increase the extract solubility. SNEDDS formulation of the extracts is not only can increase solubility but also bioavailability of the extract, so effectiveness of therapy is improved. Results showed that SNEDDS of MoringaoleiferaL.and Cassia alataL.leaves Extracts that used corn oil as oil phase, tween 80 as surfactant, and propylene glycol as the co-surfactant provided nanoemulsion with good characteristics. Emulsification time of Moringaoleifera L. and Cassia alata L. SNEDDS in Artificial Gastric Fluid (AGF) media were from 17 to 48 seconds and from 7 to 19 seconds; % transmittance ranges were from 89.40 to 90.09% and from 84.85 to 88.30%; particles size in the optimum formula were 10.7 nm and 20.2 nm; polydisperse index values were 0.012 and 0.447; and zeta potential values were -5.0 mV and -3.9 mV respectively. It can be concluded that MoringaoleiferaL.and Cassia alata L. leaves Extracts can be formulated into SNEDDS.The use of plants as traditional medicine is widely used in Indonesia society, especially in rural areas that still have plenty of plant varieties. The plants that have been used empirically and investigated to have potential efficacy as traditional medicine are MoringaoleiferaL.andCassia alata L. Leaves Extracts of Moringaoleifera L and Cassia alataL. contain several bioactive compounds and have high antioxidant activity. However, bioactive compounds of those leaves extract have low solubility in water. Hence, to be formulated into Self-Nanoemulsifying Drug Delivery System (SNEDDS) is one of the solutions to increase the extract solubility. SNEDDS formulation of the extracts is not only can increase solubility but also bioavailability of the extract, so effectiveness of therapy is improved. Results showed that SNEDDS of MoringaoleiferaL.and Cassia alataL.leaves Extracts that used corn oil as oil phase, tween 80 as surfactant, and propylene glycol as the co-surfactant provided nanoemulsion with good chara...

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PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCE, BIOTECHNOLOGY, AND BIOMETRICS 2019

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