小胶质膜在阿尔茨海默病中的作用。

4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Current topics in membranes Pub Date : 2020-01-01 DOI:10.1016/bs.ctm.2020.08.007

Jae-Won Shin, James C Lee

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引用次数: 1

摘要

大多数阿尔茨海默病(AD)的风险基因是由大脑中的小胶质细胞高度和选择性表达的。其中一些基因与脂质和胆固醇代谢、脂质合成、脂质转运、内吞作用、胞吐作用和吞噬作用有关。因此，研究细胞膜生物物理学在小胶质细胞功能中的作用有助于提高我们对阿尔茨海默病病理的认识。在本章中，我们讨论了脂筏和膜-细胞骨架粘附如何影响小胶质细胞介导的氧化应激和淀粉样蛋白-β肽(Aβ)的清除。我们还讨论了脂质膜结合的细胞外囊泡作为病理因子载体的潜在作用，以促进炎症和细胞毒性。

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Roles of microglial membranes in Alzheimer's disease.

The majority of Alzheimer's disease (AD) risk genes are highly and selectively expressed by microglia in the brain. Several of these genes are related to lipid and cholesterol metabolism, lipid synthesis, lipid transport, endocytosis, exocytosis and phagocytosis. Therefore, studying the roles of cellular membrane biophysics in microglial function should improve our understanding of the AD pathology. In this chapter, we discuss how lipid rafts and membrane-cytoskeleton adhesion impact microglial-mediated oxidative stress and clearance of amyloid-β peptide (Aβ). We also discuss potential roles of lipid membrane-bound extracellular vesicles as carriers of pathological factors to promote inflammation and cytotoxicity.

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来源期刊

Current topics in membranes 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.