乳酸、组蛋白乳酸化和癌症标志。

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Expert Reviews in Molecular Medicine Pub Date : 2023-01-09 DOI:10.1017/erm.2022.42

Xinyu Lv, Yingying Lv, Xiaofeng Dai

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引用次数: 9

摘要

组蛋白乳酸化是乳酸水平和糖酵解的一个指标，它与细胞代谢有着内在的联系，代表了一种影响细胞命运的新型表观遗传密码，包括癌变。通过描述组蛋白乳酸化与癌症特征之间的关系，我们提出组蛋白乳酸化是一种新的表观遗传密码，将细胞引向恶性状态，并主张确定新的治疗策略或针对乳酸化的双靶向模式对有效控制癌症的重要性。这篇综述支持了组蛋白乳酸化的重要但研究较少的领域，并揭示了其临床影响以及针对乳酸化的可能的治疗工具。

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Lactate, histone lactylation and cancer hallmarks.

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.

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来源期刊

Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

7.40

自引率

1.60%

发文量

期刊介绍： Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.