接种疫苗后的德尔塔病毒感染可引起对SARS-CoV-2染色体的有效中和免疫

The Indonesian Journal of Infectious Diseases Pub Date : 2022-04-16 DOI:10.1093/infdis/jiac149

Ka-Li Zhu, Huixia Gao, Lin Yao, Jun Rong, Li Yang, Zhi Zhang, Ping Jiang, L. Duan, Guo-Lin Wang, E. Dai, M. Ma

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引用次数: 4

摘要

SARS-CoV-2 Omicron (B.1.1.529)变体广泛通过疫苗或感染逃避中和抗体。我们评估了接种疫苗后德尔塔病毒感染者和德尔塔病毒感染者对SARS-CoV-2武汉-1病毒(WA1)、β、德尔塔病毒和欧米克隆病毒的血清中和活性。δ感染的血清仅能中和WA1和δ，但几乎完全丧失了中和β和Omicron的能力。然而，接种后的德尔塔病毒感染导致血清对WA1、β和Omicron的中和活性显著增加。该研究表明，突破性感染德尔塔病毒可诱导针对欧米克隆变异和其他新出现的变异的高效体液免疫反应。

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Delta infection following vaccination elicits potent neutralizing immunity against the SARS-CoV-2 Omicron

Abstract The SARS-CoV-2 Omicron (B.1.1.529) variant extensively escape neutralizing antibodies by vaccines or infection. We assessed serum neutralizing activity in sera from Delta infection following vaccination and Delta infection only against SARS-CoV-2 Wuhan-Hu-1 (WA1), Beta, Delta, and Omicron. Sera from Delta infection only could neutralize WA1 and Delta but nearly completely lost capacity to neutralize Beta and Omicron. However, Delta infection following vaccination resulted in a significant increase of serum neutralizing activity against WA1, Beta, and Omicron. This study demonstrates that breakthrough infection of Delta substantially induced high potency humoral immune response against the Omicron variant and other emerged variants.

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The Indonesian Journal of Infectious Diseases

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