{"title":"高效液相色谱法测定维甲酸-米诺地尔溶液中维甲酸的稳定性","authors":"A Zarghi, M Jenabi, A.J Ebrahimian","doi":"10.1016/S0031-6865(98)00014-4","DOIUrl":null,"url":null,"abstract":"<div><p>A new formulation of topical tretinoin–minoxidil solution was prepared and the chemical stability of tretinoin<span> was studied for 6 months at 4°C. A reversed phase high performance liquid chromatography<span> (HPLC) method was developed for determination of tretinoin using cyanocobalamine as an internal standard. Tretinoin was shown that to be stable for at least 6 months used refrigerated storage conditions.</span></span></p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 3","pages":"Pages 163-165"},"PeriodicalIF":0.0000,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00014-4","citationCount":"11","resultStr":"{\"title\":\"HPLC determination of the stability of tretinoin in tretinoin–minoxidil solution\",\"authors\":\"A Zarghi, M Jenabi, A.J Ebrahimian\",\"doi\":\"10.1016/S0031-6865(98)00014-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A new formulation of topical tretinoin–minoxidil solution was prepared and the chemical stability of tretinoin<span> was studied for 6 months at 4°C. A reversed phase high performance liquid chromatography<span> (HPLC) method was developed for determination of tretinoin using cyanocobalamine as an internal standard. Tretinoin was shown that to be stable for at least 6 months used refrigerated storage conditions.</span></span></p></div>\",\"PeriodicalId\":19830,\"journal\":{\"name\":\"Pharmaceutica acta Helvetiae\",\"volume\":\"73 3\",\"pages\":\"Pages 163-165\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00014-4\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutica acta Helvetiae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031686598000144\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HPLC determination of the stability of tretinoin in tretinoin–minoxidil solution
A new formulation of topical tretinoin–minoxidil solution was prepared and the chemical stability of tretinoin was studied for 6 months at 4°C. A reversed phase high performance liquid chromatography (HPLC) method was developed for determination of tretinoin using cyanocobalamine as an internal standard. Tretinoin was shown that to be stable for at least 6 months used refrigerated storage conditions.
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