缺乏5HT1A受体的小鼠海马功能异常和海马依赖性学习受损

CNS drug reviews Pub Date : 2006-06-07 DOI:10.1111/J.1527-3458.2000.TB00183.X

Z. Sarnyai, E. Sibille, C. Pavlides, Robert J. Fenster, B. McEwen, M. Toth

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摘要

在Morris水迷宫(MWM)的隐藏平台(空间)版本和y型迷宫的延迟版本中，KO动物在海马依赖的学习和记忆测试中表现出损伤。KO小鼠在非海马记忆任务(如MWM的可见平台(非空间)版本、y型迷宫的即时版本和工作记忆的自发交替测试)中的表现未受到损害。这些结果表明5HT

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Functional Abnormalities in the Hippocampus and Impaired Hippocampal‐dependent Learning in Mice Lacking the 5HT1A Receptors

KO animals showedimpairments in hippocampal-dependent learning and memory tests, such as the hiddenplatform (spatial) version of the Morris water maze (MWM) and the delayed version ofY-maze. Performance of KO mice was not impaired in non-hippocampal memory taskssuch as the visible platform (non-spatial) version of the MWM, the immediate version ofthe Y-maze, and the spontaneous alternation test of working memory. These resultsdemonstrate that 5HT

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CNS drug reviews

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