基尔库克省终末期肾病患者腺病毒感染率

Azzawi M. Hadi, I. Saadoon, Wirya Ahmed Tofiq
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摘要

腺病毒是一种DNA病毒,于20世纪50年代从患有非典型肺炎的新兵身上发现。大多数血清型较高水平的数字已与免疫功能低下的人隔离。虽然大多数与腺病毒相关的感染是自限性的,但那些发生在免疫功能低下个体中的感染可能要严重得多,甚至是致命的。由于病毒感染率高,肾功能衰竭的患者免疫反应减弱。本研究旨在了解终末期肾脏疾病血液透析患者的腺病毒感染情况。本研究于2019年12月11日至2020年5月5日在基尔库克市的基尔库克综合医院/透析科进行。采用酶联免疫吸附试验(ELISA)对200例血液透析患者血清腺病毒特异性免疫球蛋白G和M进行检测,其中男性108例(54%),女性92例(46%)。结果显示,142例(71%)患者有抗腺病毒IgG抗体,10例(5%)患者有抗腺病毒IgM抗体,6例(3%)患者有抗IgM抗体和抗IgG抗体。男女腺病毒血清阳性率差异无统计学意义(p>0.05)(分别为51.26%和48.74%)。研究结果显示,血清阳性与性别、年龄、居住地无显著相关。建议透析患者做腺病毒检测,以降低腺病毒传染率,避免肾移植失败。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rate of Adenovirus Infection in Patients with End Stage Renal Disease in Kirkuk Governorate
Adenovirus is a DNA virus which was discovered in 1950s from military recruit with atypical pneumonia. The majority of the higher-level number for serotypes has been insulated from immunocompromised persons. While the majority of infections linked to adenovirus are self-limiting, those who occur in immunocompromised individual can be far more serious, even deadly. Patients who have reached the end of their kidney function have weakened immune response, due to high rates of infection by virus. The goal of this research was to find out the infection with adenovirus in terminal stage of kidney disease patients who undergoing hemodialysis. This study was done in Kirkuk General Hospital/Dialysis Unit in Kirkuk city from the period 12/11/2019 to 5/5/2020. Serum of 200 hemodialysis patients were investigated for both adenovirus-specific immunoglobulin G and M by using enzyme-linked immunosorbent assay (ELISA),108 (54%) patients were males and 92 (46%) were females. The results showed that 142 patients (71%) had anti-adenovirus IgG, 10 patients (5%) had anti-adenovirus IgM and 6 patients (3%) had both anti-IgM and anti-IgG. There was no significant variance in adenovirus seropositivity (p>0.05) between males and females (51.26% and 48.74% respectively). The study showed that non-significant relation between the seropositivity and sex, age and residency. We advise to do adenovirus detection test to those patients who undergone dialysis to decrease the rate of adenoviruses contagion and to avoid renal transplantation failure.
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