斑马鱼药物戒断综合征模型(Danio rerio)

Reviews on Clinical Pharmacology and Drug Therapy Pub Date : 2022-10-03 DOI:10.17816/rcf202185-191

K. N. Zabegalov, D. Galstyan, T. Kolesnikova, Yurii M. Kositsyn, Mariya A. Gubaidullina, Gleb O. Maslov, K. Demin, S. L. Khatsko, A. Kalueff

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引用次数: 0

摘要

成瘾状态的中心病理联系是药物戒断综合征。通常，戒断综合征的严重表现与突触后受体敏感性降低(脱敏)、受体密度降低和神经递质转运受损以及反弹效应有关。斑马鱼是研究经典戒断症状和其他选定精神活性药物戒断的特殊情况的有效工具。

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Modeling the drug withdrawal syndrome in zebrafish (Danio rerio)

The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower density of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.

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来源期刊

Reviews on Clinical Pharmacology and Drug Therapy

CiteScore

0.50

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0.00%

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