Comparative characteristics of antimicrobial activity of water dispersions of silver and gold nanoparticles stabilized with native and synthetic polymers

BACKGROUND: The construction and application of antimicrobial drugs on the basis of nanoparticles of metals, silver and gold in particular, are staying casual up to now. AIM: was to study the spectrum of antimicrobial activity of nanoparticles of silver and gold developed by means of chemical recovery and stabilized with native and synthetic compounds. MATERIALS AND METHODS: The paper presents the results of a study of the antimicrobial activity of aqueous dispersions of silver and gold nanoparticles against standard and clinical strains of Staphylococcus aureus, which were sensitive to methicillin. Natural (carboxymethylcellulose, sodium oleate) and synthetic (polyvinyl alcohol, sodium dodecyl sulfate, polyazolidylammonium modified with iodine hydrate ions) polymeric compounds were used as stabilizers. RESULTS: The high antistaphylococcal activity of the studied drugs was established, which depended on the stabilizer used. The highest efficiency of biocidal action was revealed for aqueous dispersions of metal nanoparticles stabilized with polyvinyl alcohol and polyazolidylammonium modified with iodine hydrate ions, which did not depend on the strain differences of microorganisms. CONCLUSIONS: The results obtained open up prospects for the use of aqueous dispersions of silver and gold nanoparticles as active components in the development of new antiseptic preparations and photosensitizers for antimicrobial photodynamic therapy.