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Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2020-03-30 DOI:10.37360/BLACPMA.20.19.2.15

Annarli Olivia Rodríguez-Ferreiro, Dalgis Léon-Duharte, Gustavo Polanco-Durán, Frenkel Guisado-Bourzac, Ania Ochoa-Pacheco, Julio César Escalona-Arranz

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引用次数: 0

摘要

我们评估了从沙参根中提取的氯仿提取物(CE)和组分对10种人类肿瘤细胞系[白血病(K-562)、乳腺癌(MCF-7)、表达多重耐药表型的卵巢(NCI/ADR-RES)、黑色素瘤(UACC-62)、肺(NCI- h460)、前列腺(PC-3)、结肠(HT29)、卵巢(OVCAR-3)、胶质瘤(U251)和肾脏(786-0)]的体外抗增殖活性。CE具有弱至中等的抗增殖活性(平均对数GI50为1.07)，而富含海马烷型二萜[-海马烷-8(14)，15-二烯-19-酸和-8(14)，15-海马烷-3β-醇]的组分3和组分4对大多数细胞系具有中至强的抗增殖活性，平均对数GI50分别为0.62和0.59。结果表明，沙棘样品具有良好的体外抗增殖作用，其中NCI/ADR-RES、HT29和OVCAR-3的抗增殖效果最好，TGI值在5.95 ~ 28.71 μg之间。这表明这类化合物可能是发现新治疗剂的潜在原型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Estudio etnobotánico de Plectranthus neochilus Schltr (Meprobamato) en Cuba

Chloroform extract (CE) and fractions obtained from Aldama arenaria roots were evaluated for their in vitro antiproliferative activity against 10 human tumor cell lines [leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), prostate (PC-3), colon (HT29), ovary (OVCAR-3), glioma (U251), and kidney (786-0)]. CE presented weak to moderate antiproliferative activity (mean log GI50 1.07), whereas fractions 3 and 4, enriched with pimarane-type diterpenes [ent-pimara-8(14),15-dien-19-oic acid and ent-8(14),15-pimaradien-3β-ol], presented moderate to potent activity for most cell lines, with mean log GI50 of 0.62 and 0.59, respectively. The results showed promising in vitro antiproliferative action of the samples obtained from A. arenaria, with the best results for NCI/ADR-RES, HT29, and OVCAR-3, and TGI values ranging from 5.95 to 28.71 μg.ml-1, demonstrating that compounds of this class may be potential prototypes for the discovery of new therapeutic agents.

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Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants

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