I. G. Vilkova, N. S. Tropskaya, T. V. Chernen'kaya, T. S. Popova
{"title":"低氯血症实验模型中的小肠电活动","authors":"I. G. Vilkova, N. S. Tropskaya, T. V. Chernen'kaya, T. S. Popova","doi":"10.33647/2074-5982-18-3-58-61","DOIUrl":null,"url":null,"abstract":"Variations in the basic parameters of the electrical activity of the small intestine in rats were studied using an experimental model of hypochlorhydria caused by an intragastric administration of rabeprazole for 16 days. Hypochlorhydria was found to lead to an increased duration of irregular electric activity and a reduction in the period of quiescence, which indicates an increase in uncoordinated contractions of the small intestine. A decrease in the number of migrating myoelectric complexes and, consequently, a partial suppression of propulsive peristalsis contributes to an excessive bacterial overgrowth in the proximal small intestine.","PeriodicalId":14837,"journal":{"name":"Journal Biomed","volume":"50 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Small Bowel Electrical Activity in an Experimental Model of Hypochlorhydria\",\"authors\":\"I. G. Vilkova, N. S. Tropskaya, T. V. Chernen'kaya, T. S. Popova\",\"doi\":\"10.33647/2074-5982-18-3-58-61\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Variations in the basic parameters of the electrical activity of the small intestine in rats were studied using an experimental model of hypochlorhydria caused by an intragastric administration of rabeprazole for 16 days. Hypochlorhydria was found to lead to an increased duration of irregular electric activity and a reduction in the period of quiescence, which indicates an increase in uncoordinated contractions of the small intestine. A decrease in the number of migrating myoelectric complexes and, consequently, a partial suppression of propulsive peristalsis contributes to an excessive bacterial overgrowth in the proximal small intestine.\",\"PeriodicalId\":14837,\"journal\":{\"name\":\"Journal Biomed\",\"volume\":\"50 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal Biomed\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33647/2074-5982-18-3-58-61\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal Biomed","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33647/2074-5982-18-3-58-61","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Small Bowel Electrical Activity in an Experimental Model of Hypochlorhydria
Variations in the basic parameters of the electrical activity of the small intestine in rats were studied using an experimental model of hypochlorhydria caused by an intragastric administration of rabeprazole for 16 days. Hypochlorhydria was found to lead to an increased duration of irregular electric activity and a reduction in the period of quiescence, which indicates an increase in uncoordinated contractions of the small intestine. A decrease in the number of migrating myoelectric complexes and, consequently, a partial suppression of propulsive peristalsis contributes to an excessive bacterial overgrowth in the proximal small intestine.
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