[甘氨酸受体:分子组织与病理]。

G. Maleeva, P. Bregestovski
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引用次数: 1

摘要

甘氨酸受体是脊椎动物中枢神经系统中提供快速突触传递的阴离子选择通道。它与烟碱乙酰胆碱、GABA和血清素(5-HT3R)受体一起属于五聚体cys-loop受体超家族。本文就这些跨膜蛋白的主要功能、分布和分子结构作一综述。特别关注这些受体的分子生理学的最新研究,以及对其功能障碍负责的分子结构域的提出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY].
Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.
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