{"title":"二甲双胍联合胰岛素不能改善超重/肥胖青少年1型糖尿病患者的血糖控制","authors":"A. Lucas-Herald, K. Robertson","doi":"10.1136/archdischild-2016-312326","DOIUrl":null,"url":null,"abstract":"Design: Placebo-controlled randomised controlled trial.\n\nAllocation: Via computer generated sequence.\n\nBlinding: Double-blind.\n\nSetting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.\n\nPatients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.\n\nIntervention : 2000 mg daily dose metformin compared with placebo.\n\nOutcomes : Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.\n\nFollow-up period …","PeriodicalId":8153,"journal":{"name":"Archives of Disease in Childhood: Education & Practice Edition","volume":"1 1","pages":"224 - 224"},"PeriodicalIF":0.0000,"publicationDate":"2016-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Metformin with insulin does not improve the glycaemic control of overweight/obese adolescents with type 1 diabetes\",\"authors\":\"A. Lucas-Herald, K. Robertson\",\"doi\":\"10.1136/archdischild-2016-312326\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Design: Placebo-controlled randomised controlled trial.\\n\\nAllocation: Via computer generated sequence.\\n\\nBlinding: Double-blind.\\n\\nSetting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.\\n\\nPatients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.\\n\\nIntervention : 2000 mg daily dose metformin compared with placebo.\\n\\nOutcomes : Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.\\n\\nFollow-up period …\",\"PeriodicalId\":8153,\"journal\":{\"name\":\"Archives of Disease in Childhood: Education & Practice Edition\",\"volume\":\"1 1\",\"pages\":\"224 - 224\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Disease in Childhood: Education & Practice Edition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/archdischild-2016-312326\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Disease in Childhood: Education & Practice Edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/archdischild-2016-312326","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metformin with insulin does not improve the glycaemic control of overweight/obese adolescents with type 1 diabetes
Design: Placebo-controlled randomised controlled trial.
Allocation: Via computer generated sequence.
Blinding: Double-blind.
Setting: 26 paediatric endocrinology clinics in the Type 1 Diabetes Exchange Clinic Network between 2013 and 2014.
Patients: 140 adolescents aged between 12.1 and 19.6 years (mean (SD) 15.3 (1.7)) with type 1 diabetes for >1 year and a body mass index >85th centile for age, total daily insulin dose >0.8 units/kg and three times daily self-monitoring of blood glucose.
Intervention : 2000 mg daily dose metformin compared with placebo.
Outcomes : Primary outcome: change in haemoglobin A1c (HbA1c) from baseline to 26 weeks. Prespecified secondary outcomes: total daily dose (TDD) insulin per kg body weight, total basal insulin per kg body weight, anthropometry, blood pressure, metabolic profile.
Follow-up period …
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