糖尿病背景下的成熟和老年人红细胞重组

T. Pavlova, I. B. Bukhvalov, A. Kaplin, Irina I. Povalyaeva, I. Goncharov, L. A. Pavlova
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引用次数: 0

摘要

背景:现代糖尿病的高发病率要求我们需要寻找新的,包括显微镜下的机会来识别各种生理过程中的病理变化。研究目的:探讨不同类型糖尿病(1型和2型)在成熟和老年妇女中红细胞特性和参数变化的特点。材料与方法:采用原子力法和扫描探针显微镜对55例30 ~ 70岁女性静脉血进行检测,并将其分为3组(DM组、II型DM组、无内分泌病变对照组)。结果:作者发现糖尿病患者红细胞病理形态百分比增加。与对照组(DM I组12.20±2.14,DM II组10.00±1.20,对照组4.40±0.15)比较,2型糖尿病患者(30-45岁组10.00±1.20,60-70岁组13.20±1.90)比较,大细胞型红细胞数量均有所增加。同样的趋势在小细胞中也很典型。2型糖尿病患者红细胞几何参数的老年变化表现为红细胞体积增加,红细胞最大高度随患者年龄的增加而增加。结论:原子力显微镜在红细胞生物物理参数研究中的应用使鉴定paОригинальная статья成为可能。2021;7(4):400-409生物医学研究成果。2021:7(4):400-409通过测定大细胞、小细胞数量和红细胞病理改变形式增加,红细胞平均体积和面积减少等变化来确定高危人群401例患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Restructuring of erythrocytes in persons of mature and elderly age on the background of diabetes mellitus
Background: The high incidence of diabetes mellitus in modern conditions dictates the need to search for new, including microscopic, opportunities to identify pathological changes in the course of various physiological processes. The aim of the study: To study the peculiarities of changes in the properties and parameters of erythrocytes in various types of diabetes mellitus (types 1 and 2) in women of mature and elderly age. Materials and methods: Venous blood of 55 women aged 30 to 70 years, divided into study groups (women with type DM, women with type II DM, control without endocrinopathy) was examined using atomic force and scanning probe microscopy. Results: The authors found an increase in the percentage of pathological forms of erythrocytes in patients with diabetes mellitus. An increase in the number of macrocytic forms of erythrocytes was observed not only when compared with the control group (DM I 12.20±2.14, DM II 10.00±1.20, control 4.40±0.15), but and when comparing two age groups of patients with type 2 DM (30-45 years old 10.00±1.20, 60-70 years old 13.20±1.90). The same tendency is typical for microcytes. Geriatric changes in the geometric parameters of erythrocytes in the group of patients with type 2 DM were characterized by an increase in the volume, as well as the maximum height of erythrocytes with increasing age of the patients. Conclusion: The use of atomic force microscopy in the study of the biophysical parameters of erythrocytes makes it possible to identify paОригинальная статья Original article Научные результаты биомедицинских исследований. 2021;7(4:400-409 Research Results in Biomedicine. 2021:7(4):400-409 401 tients from high-risk groups by determining such changes as an increase in the number of macrocytes, microcytes and pathologically altered forms of erythrocytes, a decrease in the average volume and area of erythrocytes.
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