{"title":"阿米替林与舍曲林治疗糖尿病神经病变的比较研究","authors":"Talha Jawaid, A. Shakya, M. Kamal, S. Hussain","doi":"10.4314/IJHR.V1I2.47918","DOIUrl":null,"url":null,"abstract":"Purpose: To investigate the effect of amitriptyline (Ami) and sertraline (Sert) in diabetes neuropathy. \nMethods: Diabetes was induced in 3 groups of rats (n=6) with \nstreptozotocin (STZ, 55mg/kg, i.p.). Two of the groups of diabetic rats received amitriptyline (15 mg/kg, p.o) and sertraline (30 mg/kg, p.o.) while another 2 groups (n=6) received the same drug treatment without prior administration of STZ. A normal group (n=6) of rats and STZ-induced group (n=6) of diabetic rats served as controls. The blood glucose, glycosylated hemoglobin (GHb), pain sensitivity and neuromuscular strength in all the rats were determined. \nResults: Ami (15mg/kg, p.o.) produced severe hyperglycemia (p Keywords: Amitriptyline; sertraline; diabetic neuropathy; glycosylated haemoglobin (GHb); streptozotocin-induced diabetes.","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"22 1","pages":"73-78"},"PeriodicalIF":0.0000,"publicationDate":"2009-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Amitriptyline and Sertraline in Diabetic Neuropathy: A Comparative View\",\"authors\":\"Talha Jawaid, A. Shakya, M. Kamal, S. Hussain\",\"doi\":\"10.4314/IJHR.V1I2.47918\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: To investigate the effect of amitriptyline (Ami) and sertraline (Sert) in diabetes neuropathy. \\nMethods: Diabetes was induced in 3 groups of rats (n=6) with \\nstreptozotocin (STZ, 55mg/kg, i.p.). Two of the groups of diabetic rats received amitriptyline (15 mg/kg, p.o) and sertraline (30 mg/kg, p.o.) while another 2 groups (n=6) received the same drug treatment without prior administration of STZ. A normal group (n=6) of rats and STZ-induced group (n=6) of diabetic rats served as controls. The blood glucose, glycosylated hemoglobin (GHb), pain sensitivity and neuromuscular strength in all the rats were determined. \\nResults: Ami (15mg/kg, p.o.) produced severe hyperglycemia (p Keywords: Amitriptyline; sertraline; diabetic neuropathy; glycosylated haemoglobin (GHb); streptozotocin-induced diabetes.\",\"PeriodicalId\":93450,\"journal\":{\"name\":\"International journal of health research and innovation\",\"volume\":\"22 1\",\"pages\":\"73-78\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-11-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of health research and innovation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/IJHR.V1I2.47918\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of health research and innovation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/IJHR.V1I2.47918","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Amitriptyline and Sertraline in Diabetic Neuropathy: A Comparative View
Purpose: To investigate the effect of amitriptyline (Ami) and sertraline (Sert) in diabetes neuropathy.
Methods: Diabetes was induced in 3 groups of rats (n=6) with
streptozotocin (STZ, 55mg/kg, i.p.). Two of the groups of diabetic rats received amitriptyline (15 mg/kg, p.o) and sertraline (30 mg/kg, p.o.) while another 2 groups (n=6) received the same drug treatment without prior administration of STZ. A normal group (n=6) of rats and STZ-induced group (n=6) of diabetic rats served as controls. The blood glucose, glycosylated hemoglobin (GHb), pain sensitivity and neuromuscular strength in all the rats were determined.
Results: Ami (15mg/kg, p.o.) produced severe hyperglycemia (p Keywords: Amitriptyline; sertraline; diabetic neuropathy; glycosylated haemoglobin (GHb); streptozotocin-induced diabetes.
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