壶腹周围癌的DNA分析。

H. Katagiri, I. Okayasu, M. Endo
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引用次数: 2

摘要

71例壶腹周围癌(27例为胰头癌(Ph))的核DNA含量;24、壶腹癌(A);20、下总胆管癌(Bi)采用原发病变档案石蜡包埋标本进行细胞荧光测定。分析其预后、肿瘤大小、组织学分化、淋巴结转移、淋巴浸润、静脉浸润、神经周围浸润和生长方式的关系。结果表明,在肿瘤最大尺寸2.1 ~ 4cm、分化良好的腺癌、有无淋巴结转移、有无静脉浸润、淋巴浸润、神经周围浸润、介于扩张性和浸润性之间的生长模式等相同条件下,“Ph”的预后较其他两种差,DNA含量较高。总之,本研究表明DNA含量与预后密切相关,DNA分析对壶腹周围癌患者预后的预测具有重要的临床价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
DNA analysis of periampullary cancers.
The nuclear DNA content in 71 cases of periampullary cancer (27, cancer of the head of the pancreas (Ph); 24, cancer of the ampulla of Vater (A); and 20, cancer of the inferior common bile duct (Bi] was measured cytofluorometrically using the archival paraffin-embedded specimens of the primary lesions. They were analyzed in relation to prognosis, tumor size, histological differentiation, lymph node metastasis, lymphatic invasion, venous invasion, perineural invasion, and growth pattern. The results show that "Ph" has more unfavorable prognosis compared with the other two and it has more DNA content under the same conditions such as tumor from 2.1 to 4 cm in its greatest dimension, well differentiated adenocarcinoma, with or without lymph node metastasis, with or without venous invasion, with lymphatic invasion, with perineural invasion, and in the intermediate growth pattern between expansive and infiltrative. In conclusion, this study demonstrates a close correlation between the DNA content and prognosis and the significant clinical value of DNA analysis for predicting the prognosis in patients of periampullary cancer.
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