眼部给药系统(ODDS):探讨提高ODDS的挑战和途径

Suraj Mandal, Km Shiva, K. P. Kumar, Sweta Goel, Ramesh Patel, Shweta Sharma, Renu Chaudhary, Arti Bhati, Netra Pal, Ashwani Dixit
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引用次数: 1

摘要

眼睛独特的生命结构和生理特征给视觉药物传输框架的研究带来了巨大的困难。就近输液是治疗前列病最合适、最合理的用药组织技术。眼科药物输送框架存在两种障碍:静态边界和动态边界。静态片层包含角膜、真皮、视网膜和视网膜血管,而动态片层包含胎盘血流、结膜、泪液排出和淋巴渗漏。这些限制影响药物的生物利用度。本文考察了习惯眼科实践的局限性和影响眼睛药代动力学的中心点。同样,眼膏、凝胶、前药、鼻内输液、增稠剂、入口能量剂、脂质体、微颗粒、纳米颗粒、视觉输液、插入物、纳米颗粒、纳米结构、微乳液、凝胶和眼周输液。保证了药物的生物利用度,保证了药物在前肺泡和后肺泡的可控和恒定控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ocular drug delivery system (ODDS): Exploration the challenges and approaches to improve ODDS
The remarkable life structures and physiology of the eye presents huge difficulties to researchers in the field of visual medication conveyance frameworks. Nearby infusion is the most fitting and proper medication organization technique for the treatment of foremost front sickness. There are two kinds of hindrances in ophthalmic medication conveyance frameworks: static boundaries and dynamic obstructions. Static lamellae contain corneal, dermal, retinal, and retinal vessels while dynamic lamellae contain placental blood stream, conjunctiva, tear evacuation, and lymphatic seepage. These limitations influence the bioavailability of the medication. This article examines the limits of customary ophthalmic practice and the central point affecting the pharmacokinetics of the eye. Likewise, eye salves, gels, prodrugs, intranasal infusions, thickeners, entrance energizers, liposomes, microparticles, nanoparticles, visual infusions, inserts, nanoparticles, nanostructures, microemulsions, gels and periocular infusions. It guarantees the bioavailability of the medication and the controlled and constant control of the medication in the foremost and back alveoli.
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