M.E. Taylor , J. McCarvil , I.M. Feavers , D.M. Jones , A.J. Fox
{"title":"利用重组大肠杆菌LamB蛋白研究人对单个脑膜炎球菌PorA外膜蛋白表位的抗体反应","authors":"M.E. Taylor , J. McCarvil , I.M. Feavers , D.M. Jones , A.J. Fox","doi":"10.1016/S0888-0786(96)01065-7","DOIUrl":null,"url":null,"abstract":"<div><p>Recombinant <em>Escherichia coli</em> LamB proteins containing meningococcal PorA epitopes were used for the analysis of the human antibody response to specific PorA epitopes. Sera from meningococcal cases, carriers and controls were examined by an ELISA-inhibition assay. Antibody to the serosubtype P1.16 epitope was detected with similar frequency regardless of whether recombinant <em>E. coli</em> LamB protein containing P1.16 or SDS-PAGE purified meningococcal class 1 protein (serosubtype P1.16) was used as the antigen.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"8 3","pages":"Pages 137-143"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0888-0786(96)01065-7","citationCount":"0","resultStr":"{\"title\":\"The use of recombinant Escherichia coli LamB protein to study the human antibody response to an individual meningococcal PorA outer membrane protein epitope\",\"authors\":\"M.E. Taylor , J. McCarvil , I.M. Feavers , D.M. Jones , A.J. Fox\",\"doi\":\"10.1016/S0888-0786(96)01065-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Recombinant <em>Escherichia coli</em> LamB proteins containing meningococcal PorA epitopes were used for the analysis of the human antibody response to specific PorA epitopes. Sera from meningococcal cases, carriers and controls were examined by an ELISA-inhibition assay. Antibody to the serosubtype P1.16 epitope was detected with similar frequency regardless of whether recombinant <em>E. coli</em> LamB protein containing P1.16 or SDS-PAGE purified meningococcal class 1 protein (serosubtype P1.16) was used as the antigen.</p></div>\",\"PeriodicalId\":101161,\"journal\":{\"name\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"volume\":\"8 3\",\"pages\":\"Pages 137-143\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0888-0786(96)01065-7\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0888078696010657\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serodiagnosis and Immunotherapy in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0888078696010657","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The use of recombinant Escherichia coli LamB protein to study the human antibody response to an individual meningococcal PorA outer membrane protein epitope
Recombinant Escherichia coli LamB proteins containing meningococcal PorA epitopes were used for the analysis of the human antibody response to specific PorA epitopes. Sera from meningococcal cases, carriers and controls were examined by an ELISA-inhibition assay. Antibody to the serosubtype P1.16 epitope was detected with similar frequency regardless of whether recombinant E. coli LamB protein containing P1.16 or SDS-PAGE purified meningococcal class 1 protein (serosubtype P1.16) was used as the antigen.
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