维生素d3强化山羊开菲尔对糖尿病褐家鼠血浆纤维蛋白原水平的影响

Jurnal Gizi Indonesia The Indonesian Journal of Nutrition Pub Date : 2023-06-24 DOI:10.14710/jgi.11.2.77-84

Tania Masha, Astika Widy Utomo, M. Ardiaria, A. Syauqy, A. Rahadiyanti, C. Nissa, Mutiara Irma Maharani, Fairuz Zulfa, B. Panunggal

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The 35-day intervention was conducted, the goat kefir dose was 2 ml/200 g BW/day and the vitamin D dose 600 IU. Fasting blood glucose and plasma fibrinogen were assessed pre- and post-intervention. Blood glucose level was evaluated by GOD-PAP method, while plasma fibrinogen was assessed by Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were analysed with paired t-test and One-Way ANOVA. Results: There were not significant difference levels of fibrinogen between groups. The intervention groups both showed an insignificant decrease of plasma fibrinogen. The plasma fibrinogen of group treated with vitamin D3-fortified goat kefir went down to 13.47 mg/dl from 16.49 mg/dl (p = 0.49). Meanwhile, the group treated with unfortified goat kefir showed a decrease from 26.81 mg/dl to 24.94 mg/dl (p=0.83). 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引用次数: 0

摘要

摘要背景:糖尿病常与并发症的发生有关。止血因子，特别是高纤维蛋白原血症，是并发症的常见原因。山羊开菲尔和维生素D3可以作为一种抗氧化剂和抗炎症剂，可以修复胰腺细胞。目的:探讨维生素d3强化羊奶对糖尿病大鼠血浆纤维蛋白原水平的影响。材料与方法:本研究为实验研究，采用前-后单组设计。样本为21只雄性大鼠，分为四组;阴性对照(K-)、阳性对照(K +)，分别用未加维生素d3的山羊开菲尔处理(P1)和加维生素d3的山羊开菲尔处理(P2)。进行35天的干预，山羊开菲尔剂量为2 ml/200 g BW/天，维生素D剂量为600 IU。干预前后分别评估空腹血糖和血浆纤维蛋白原。采用GOD-PAP法测定血糖水平，ELISA法测定血浆纤维蛋白原。数据分析采用配对t检验和单因素方差分析。结果:两组间纤维蛋白原水平无显著性差异。干预组血浆纤维蛋白原水平均无明显下降。维生素d3强化山羊开菲尔组血浆纤维蛋白原由16.49 mg/dl降至13.47 mg/dl (p = 0.49)。与此同时，未经强化的山羊开菲尔组从26.81 mg/dl降至24.94 mg/dl (p=0.83)。另一方面，服用维生素d3强化山羊开菲尔组的空腹血糖从181.75 mg/dl显著降低到116.25 mg/dl (p=0.03)。结论添加维生素d3的山羊开菲尔能降低空腹血糖，但不能降低血浆纤维蛋白原。关键词:糖尿病;空腹血糖;纤维蛋白原;山羊酸乳酒;维生素D3强化

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STUDY OF VITAMIN D3-FORTIFIED GOAT KEFIR ON PLASMA FIBRINOGEN LEVELS OF DIABETIC RATTUS NORVEGICUS RATS

ABSTRACTBackground: Diabetes mellitus is often associated with the occurrence of complications. Haemostatic factors, especially hyperfibrinogenaemia, is a common cause of the complication. Goat kefir and vitamin D3 may act as an antioxidant and anti-inflammation agent which can repair pancreatic beta cells.Objectives: This study aimed to analyse the effect of vitamin D3-fortified goat milk and plasma fibrinogen levels in diabetic rats. Materials and Methods: This study was an experimental study with pre-post only group design. The samples were 21 male rats divided into four groups; negative control (K-), positive control (K +), treated with unfortified goat kefir (P1), and treated with vitamin D3-fortified goat kefir (P2). The 35-day intervention was conducted, the goat kefir dose was 2 ml/200 g BW/day and the vitamin D dose 600 IU. Fasting blood glucose and plasma fibrinogen were assessed pre- and post-intervention. Blood glucose level was evaluated by GOD-PAP method, while plasma fibrinogen was assessed by Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were analysed with paired t-test and One-Way ANOVA. Results: There were not significant difference levels of fibrinogen between groups. The intervention groups both showed an insignificant decrease of plasma fibrinogen. The plasma fibrinogen of group treated with vitamin D3-fortified goat kefir went down to 13.47 mg/dl from 16.49 mg/dl (p = 0.49). Meanwhile, the group treated with unfortified goat kefir showed a decrease from 26.81 mg/dl to 24.94 mg/dl (p=0.83). On the other hand, there was a significant decrease in fasting blood glucose in the group treated with vitamin D3-fortified goat kefir from 181.75 mg/dl to 116.25 mg/dl (p=0.03).Conclusion Our results demonstrate that administration of vitamin D3-fortified goat kefir can decrease fasting blood glucose but not in plasma fibrinogen. Keywords : Diabetes Mellitus; Fastin blood glucose; Fibrinogen; Goat kefir; Vitamin D3 Fortification

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Jurnal Gizi Indonesia The Indonesian Journal of Nutrition

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8 weeks