{"title":"联合治疗:消除HBV cccDNA的关键","authors":"K. Baruti","doi":"10.35248/1948-5964.20.S10.E002","DOIUrl":null,"url":null,"abstract":"Hepatitis B Virus (HBV) poses a significant global health problem, with approximately 257 million individuals chronically infected worldwide, causing 887 000 deaths per annum [1]. Healthy individuals are able to resolve infection within the first six months of infection (acute stage). However, infection may persist for longer than 6 months resulting in Chronic Hepatitis B infection (CHB), which is characterized by the presence of the Hepatitis B virus surface Antigen (HBsAg) [1]. Furthermore, CHB results in complications such as cirrhosis, endstage liver disease and hepatocellular carcinoma, which are the causes of high mortality rates [1].","PeriodicalId":15020,"journal":{"name":"Journal of Antivirals & Antiretrovirals","volume":"105 1","pages":"1-1"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Combination Therapy: A Key to The Elimination of HBV cccDNA\",\"authors\":\"K. Baruti\",\"doi\":\"10.35248/1948-5964.20.S10.E002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hepatitis B Virus (HBV) poses a significant global health problem, with approximately 257 million individuals chronically infected worldwide, causing 887 000 deaths per annum [1]. Healthy individuals are able to resolve infection within the first six months of infection (acute stage). However, infection may persist for longer than 6 months resulting in Chronic Hepatitis B infection (CHB), which is characterized by the presence of the Hepatitis B virus surface Antigen (HBsAg) [1]. Furthermore, CHB results in complications such as cirrhosis, endstage liver disease and hepatocellular carcinoma, which are the causes of high mortality rates [1].\",\"PeriodicalId\":15020,\"journal\":{\"name\":\"Journal of Antivirals & Antiretrovirals\",\"volume\":\"105 1\",\"pages\":\"1-1\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Antivirals & Antiretrovirals\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35248/1948-5964.20.S10.E002\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Antivirals & Antiretrovirals","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35248/1948-5964.20.S10.E002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Combination Therapy: A Key to The Elimination of HBV cccDNA
Hepatitis B Virus (HBV) poses a significant global health problem, with approximately 257 million individuals chronically infected worldwide, causing 887 000 deaths per annum [1]. Healthy individuals are able to resolve infection within the first six months of infection (acute stage). However, infection may persist for longer than 6 months resulting in Chronic Hepatitis B infection (CHB), which is characterized by the presence of the Hepatitis B virus surface Antigen (HBsAg) [1]. Furthermore, CHB results in complications such as cirrhosis, endstage liver disease and hepatocellular carcinoma, which are the causes of high mortality rates [1].
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