CCL1/ ccr8依赖的前馈机制驱动ILC2在2型介导的炎症中的功能

The Tokushima journal of experimental medicine Pub Date : 2019-09-19 DOI:10.1084/jem.20182111

L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz

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引用次数: 36

摘要

Knipfer等人发现在2型免疫应答过程中，2型相关趋化因子受体CCR8在ILC2功能中的关键作用。CCR8通过自分泌配体CCL1支持ILC2存活。作者证明了CCL1/CCR8信号可以防止蠕虫感染。

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A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation

Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.

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The Tokushima journal of experimental medicine

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