{"title":"无线植入物神经递质检测的集成恒电位器设计","authors":"S. Yilmaz, T. Constandinou, S. Carrara","doi":"10.1109/MWSCAS47672.2021.9531719","DOIUrl":null,"url":null,"abstract":"This paper presents a novel implantable electro- chemical sensor with a built-in readout circuit, with an ultimate aim of measuring dopamine levels in human striatum. The chosen material as the ultra-micro electrode (UME) of the sensor is niobium wire around which a carbon nanospike layer is grown (Nb/CNS) by means of plasma-enhanced chemical vapor deposition. The main focus of this paper is the design of an ultra- low-power wide-range dual-slope analog-to-digital converter that is specifically designed for an Nb/CNS probe to measure Fast- Scan Cyclic Voltammetry (FSCV) current pulses within the range of ±2.56 µA. The dual-slope ADC has a sampling rate of 10 kHz with a 10 MHz clock frequency while requiring an average power consumption of 1.57 µW. The circuit has a root-mean-squared input noise of 30 pA, a resolution of 100 pA and a dynamic range of 58 dB with a 10-bit output.","PeriodicalId":6792,"journal":{"name":"2021 IEEE International Midwest Symposium on Circuits and Systems (MWSCAS)","volume":"1 1","pages":"848-852"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Integrated Potentiostat Design for Neurotransmitter Detection in Wireless Implants\",\"authors\":\"S. Yilmaz, T. Constandinou, S. Carrara\",\"doi\":\"10.1109/MWSCAS47672.2021.9531719\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper presents a novel implantable electro- chemical sensor with a built-in readout circuit, with an ultimate aim of measuring dopamine levels in human striatum. The chosen material as the ultra-micro electrode (UME) of the sensor is niobium wire around which a carbon nanospike layer is grown (Nb/CNS) by means of plasma-enhanced chemical vapor deposition. The main focus of this paper is the design of an ultra- low-power wide-range dual-slope analog-to-digital converter that is specifically designed for an Nb/CNS probe to measure Fast- Scan Cyclic Voltammetry (FSCV) current pulses within the range of ±2.56 µA. The dual-slope ADC has a sampling rate of 10 kHz with a 10 MHz clock frequency while requiring an average power consumption of 1.57 µW. The circuit has a root-mean-squared input noise of 30 pA, a resolution of 100 pA and a dynamic range of 58 dB with a 10-bit output.\",\"PeriodicalId\":6792,\"journal\":{\"name\":\"2021 IEEE International Midwest Symposium on Circuits and Systems (MWSCAS)\",\"volume\":\"1 1\",\"pages\":\"848-852\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2021 IEEE International Midwest Symposium on Circuits and Systems (MWSCAS)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/MWSCAS47672.2021.9531719\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2021 IEEE International Midwest Symposium on Circuits and Systems (MWSCAS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MWSCAS47672.2021.9531719","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Integrated Potentiostat Design for Neurotransmitter Detection in Wireless Implants
This paper presents a novel implantable electro- chemical sensor with a built-in readout circuit, with an ultimate aim of measuring dopamine levels in human striatum. The chosen material as the ultra-micro electrode (UME) of the sensor is niobium wire around which a carbon nanospike layer is grown (Nb/CNS) by means of plasma-enhanced chemical vapor deposition. The main focus of this paper is the design of an ultra- low-power wide-range dual-slope analog-to-digital converter that is specifically designed for an Nb/CNS probe to measure Fast- Scan Cyclic Voltammetry (FSCV) current pulses within the range of ±2.56 µA. The dual-slope ADC has a sampling rate of 10 kHz with a 10 MHz clock frequency while requiring an average power consumption of 1.57 µW. The circuit has a root-mean-squared input noise of 30 pA, a resolution of 100 pA and a dynamic range of 58 dB with a 10-bit output.
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