记忆的心理生物学:迈向记忆形成的模型

Marie E. Gibbs , Kim T. Ng
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引用次数: 298

摘要

使用抑制性药物和拮抗剂的证据表明,记忆形成有三个阶段的模型,阶段顺序依赖。学习后钾电导变化引起的超极化被认为是短期记忆阶段形成的基础。与钠泵活性相关的超极化似乎参与了后续不稳定相的形成。长期记忆的形成似乎涉及在不稳定相形成过程中钠泵相关的氨基酸摄取。蛋白质合成被认为是长期记忆形成的基础。虽然参考了文献中现有的证据,但本综述详细讨论了我们实验室的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychobiology of memory: Towards a model of memory formation

Evidence from the use of inhibitory drugs and antagonists to these drugs suggest a three phase model of memory formation, with phases sequentially dependent. Hyperpolarization due to potassium conductance changes following learning are postulated to underlie the formation of a short-term memory phase. Hyperpolarization associated with sodium pump activity appears to be involved in the formation of the succeeding labile phase. Long-term memory formation appears to involve sodium pump associated amino acid uptake occuring during labile phase formation. Protein synthesis is accepted as underlying the formation of long-term memory. Although reference is made to available evidence in the literature, this review deals in detail with evidence from our laboratories.

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