{"title":"记忆的心理生物学:迈向记忆形成的模型","authors":"Marie E. Gibbs , Kim T. Ng","doi":"10.1016/0147-7552(77)90017-1","DOIUrl":null,"url":null,"abstract":"<div><p>Evidence from the use of inhibitory drugs and antagonists to these drugs suggest a three phase model of memory formation, with phases sequentially dependent. Hyperpolarization due to potassium conductance changes following learning are postulated to underlie the formation of a short-term memory phase. Hyperpolarization associated with sodium pump activity appears to be involved in the formation of the succeeding labile phase. Long-term memory formation appears to involve sodium pump associated amino acid uptake occuring during labile phase formation. Protein synthesis is accepted as underlying the formation of long-term memory. Although reference is made to available evidence in the literature, this review deals in detail with evidence from our laboratories.</p></div>","PeriodicalId":100157,"journal":{"name":"Biobehavioral Reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1977-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0147-7552(77)90017-1","citationCount":"298","resultStr":"{\"title\":\"Psychobiology of memory: Towards a model of memory formation\",\"authors\":\"Marie E. Gibbs , Kim T. Ng\",\"doi\":\"10.1016/0147-7552(77)90017-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Evidence from the use of inhibitory drugs and antagonists to these drugs suggest a three phase model of memory formation, with phases sequentially dependent. Hyperpolarization due to potassium conductance changes following learning are postulated to underlie the formation of a short-term memory phase. Hyperpolarization associated with sodium pump activity appears to be involved in the formation of the succeeding labile phase. Long-term memory formation appears to involve sodium pump associated amino acid uptake occuring during labile phase formation. Protein synthesis is accepted as underlying the formation of long-term memory. Although reference is made to available evidence in the literature, this review deals in detail with evidence from our laboratories.</p></div>\",\"PeriodicalId\":100157,\"journal\":{\"name\":\"Biobehavioral Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0147-7552(77)90017-1\",\"citationCount\":\"298\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biobehavioral Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0147755277900171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biobehavioral Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0147755277900171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Psychobiology of memory: Towards a model of memory formation
Evidence from the use of inhibitory drugs and antagonists to these drugs suggest a three phase model of memory formation, with phases sequentially dependent. Hyperpolarization due to potassium conductance changes following learning are postulated to underlie the formation of a short-term memory phase. Hyperpolarization associated with sodium pump activity appears to be involved in the formation of the succeeding labile phase. Long-term memory formation appears to involve sodium pump associated amino acid uptake occuring during labile phase formation. Protein synthesis is accepted as underlying the formation of long-term memory. Although reference is made to available evidence in the literature, this review deals in detail with evidence from our laboratories.